Zhou Guanwen, Yan Keqiang, Liu Jikai, Gao Lijian, Jiang Xianzhou, Fan Yidong
Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Urology, Dezhou People's Hospital, Dezhou, China.
Cell Death Discov. 2021 Nov 1;7(1):329. doi: 10.1038/s41420-021-00724-5.
The aberrant expression of fat mass and obesity-associated protein (FTO) has been confirmed to be associated with a variety of cancers and participates in the regulation of multiple biological behaviours. FTO plays an oncogenic role in bladder cancer, but few studies have focused on how FTO promotes bladder cancer progression by regulating miRNA synthesis. Here, we confirmed that FTO expression was significantly increased in bladder cancer and was associated with a poor prognosis. FTO overexpression promoted bladder cancer cell proliferation, whereas FTO knockdown inhibited bladder cancer cell proliferation. We also demonstrated that FTO promoted bladder cancer cell proliferation via the FTO/miR-576/CDK6 pathways. Taken together, our work revealed that FTO plays a critical role in bladder cancer and could be a potential diagnostic or prognostic biomarker for this disease.
脂肪量与肥胖相关蛋白（FTO）的异常表达已被证实与多种癌症相关，并参与多种生物学行为的调控。FTO在膀胱癌中发挥致癌作用，但很少有研究关注FTO如何通过调节miRNA合成促进膀胱癌进展。在此，我们证实FTO在膀胱癌中的表达显著增加，且与预后不良相关。FTO过表达促进膀胱癌细胞增殖，而FTO敲低则抑制膀胱癌细胞增殖。我们还证明FTO通过FTO/miR-576/CDK6途径促进膀胱癌细胞增殖。综上所述，我们的研究揭示了FTO在膀胱癌中起关键作用，可能是该疾病潜在的诊断或预后生物标志物。
