Scotland´s Rural College, Edinburgh, UK.
Universitat Politècnica de València, Valencia, Spain.
Commun Biol. 2021 Nov 1;4(1):1246. doi: 10.1038/s42003-021-02784-w.
Our study provides an exhaustive comparison of the microbiome core functionalities (captured by 3,936 microbial gene abundances) between hosts with divergent genotypes for intramuscular lipid deposition. After 10 generations of divergent selection for intramuscular fat in rabbits and 4.14 phenotypic standard deviations (SD) of selection response, we applied a combination of compositional and multivariate statistical techniques to identify 122 cecum microbial genes with differential abundances between the lines (ranging from -0.75 to +0.73 SD). This work elucidates that microbial biosynthesis lipopolysaccharides, peptidoglycans, lipoproteins, mucin components, and NADH reductases, amongst others, are influenced by the host genetic determination for lipid accretion in muscle. We also differentiated between host-genetically influenced microbial mechanisms regulating lipid deposition in body or intramuscular reservoirs, with only 28 out of 122 MGs commonly contributing to both. Importantly, the results of this study are of relevant interest for the efficient development of strategies fighting obesity.
我们的研究提供了对微生物组核心功能（由 3936 个微生物基因丰度捕捉）的详尽比较，这些功能在肌肉内脂肪沉积基因型不同的宿主之间存在差异。在对家兔进行了 10 代肌肉内脂肪的分歧选择后，选择响应的表型标准差为 4.14，我们应用了组合成分和多变量统计技术，在这两个系之间识别出了 122 个盲肠微生物基因的丰度存在差异（范围从-0.75 到+0.73 SD）。这项工作阐明了微生物生物合成脂多糖、肽聚糖、脂蛋白、粘蛋白成分和 NADH 还原酶等，受宿主对肌肉中脂肪积累的遗传决定的影响。我们还区分了宿主遗传影响的微生物机制，调节体内或肌肉内储存的脂肪沉积，其中只有 122 个 MG 中的 28 个对两者都有贡献。重要的是，这项研究的结果对有效开发对抗肥胖的策略具有重要意义。
