宿主基因对微生物组的影响。
The influence of host genetics on the microbiome.
作者信息
Tabrett Alexandra, Horton Matthew W
机构信息
Plant and Microbial Biology, University of Zurich, Zurich, CH-8008, Switzerland.
出版信息
F1000Res. 2020 Feb 5;9. doi: 10.12688/f1000research.20835.1. eCollection 2020.
Abstract
It is well understood that genetic differences among hosts contribute to variation in pathogen susceptibility and the ability to associate with symbionts. However, it remains unclear just how influential host genes are in shaping the overall microbiome. Studies of both animal and plant microbial communities indicate that host genes impact species richness and the abundances of individual taxa. Analyses of beta diversity (that is, overall similarity), on the other hand, often conclude that hosts play a minor role in shaping microbial communities. In this review, we discuss recent attempts to identify the factors that shape host microbial communities and whether our understanding of these communities is affected by the traits chosen to represent them.
摘要
宿主之间的基因差异会导致病原体易感性以及与共生体关联能力的变化，这一点已得到充分理解。然而，宿主基因在塑造整体微生物组方面究竟有多大影响力仍不清楚。对动物和植物微生物群落的研究表明，宿主基因会影响物种丰富度和各个分类单元的丰度。另一方面，对β多样性（即总体相似性）的分析往往得出结论，宿主在塑造微生物群落方面作用较小。在本综述中，我们讨论了最近为确定塑造宿主微生物群落的因素所做的尝试，以及我们对这些群落的理解是否受到用于表征它们的特征的影响。
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