Campana Mario S, Riofrio Maria, Jadav Raja S, Rozenek Mattan
St. Barnabas Hospital, Department of Internal Medicine, SBH Health System, The Bronx, NY 10457, USA.
Case Rep Endocrinol. 2021 Oct 23;2021:1776538. doi: 10.1155/2021/1776538. eCollection 2021.
Patients with hyperthyroidism or thyrotoxicosis present with an unspecific constellation of signs or symptoms such as palpitations, tremors, weight loss, or diarrhea. In some severe cases, hyperthyroidism can predispose patients to metabolic abnormalities and arrhythmias. Thyrotoxic periodic paralysis (TTP) is a rare, life-threatening complication or variant of hyperthyroidism associated with hypokalemia and muscle weakness that affects young Asian or Hispanic males between 20-40 years. TTP is reversible, and the management consists of beta-blockers, antithyroid therapy, and conservative potassium correction to prevent severe cardiovascular events such as ventricular arrhythmias with the improvement of transient muscle paralysis. We present a case of a 21-year-old Hispanic male complaining with symptoms of thyrotoxicosis, marked hypokalemia, and severe generalized muscle weakness. Physicians must be aware of this uncommon complication of thyrotoxicosis called thyrotoxic periodic paralysis (TTP) to avoid potassium overcorrection and all the endocrine associations with this pathology.
甲状腺功能亢进或甲状腺毒症患者会出现一系列非特异性的体征或症状，如心悸、震颤、体重减轻或腹泻。在一些严重病例中，甲状腺功能亢进会使患者易患代谢异常和心律失常。甲状腺毒症性周期性瘫痪（TPP）是一种罕见的、危及生命的甲状腺功能亢进并发症或变异型，与低钾血症和肌肉无力有关，影响20至40岁的年轻亚洲或西班牙裔男性。TPP是可逆的，治疗包括使用β受体阻滞剂、抗甲状腺治疗以及保守的补钾措施，以预防严重的心血管事件，如室性心律失常，并改善短暂性肌肉麻痹。我们报告一例21岁西班牙裔男性病例，该患者有甲状腺毒症症状、明显低钾血症和严重的全身肌肉无力。医生必须了解这种甲状腺毒症的罕见并发症——甲状腺毒症性周期性瘫痪（TPP），以避免过度补钾以及该病症的所有内分泌相关问题。
