Elenius Henrik, Cesa Marie, Nava Suarez Corina C, Nimkar Abhishek, Basak Prasanta, Sinha Nandita
Montefiore New Rochelle Hospital, 16 Guion Pl, New Rochelle, NY 10801, USA.
Case Rep Endocrinol. 2021 Mar 16;2021:6622658. doi: 10.1155/2021/6622658. eCollection 2021.
Thyrotoxic periodic paralysis (TPP) is a rare muscular disorder, characterized by muscle weakness and hypokalemia triggered by thyrotoxicosis. In Asian populations, 2% of patients with thyrotoxicosis are affected, compared to only 0.1-0.2% of non-Asians. The vast majority of patients are male. Muscle weakness ranges in severity from very mild to life-threatening, due to respiratory compromise. We present a case of a previously healthy 39-year-old Hispanic male who presented with sudden quadriparesis and quickly recovered after being treated for hypokalemia and thyrotoxicosis. TPP, although unusual, is important to recognize as it is a potentially fatal condition that requires close monitoring and is readily reversible with appropriate therapy. Any cause of thyroid hormone excess can cause TPP, with Graves' disease being the most common etiology. Acute treatment includes potassium repletion, while long-term management focuses on determining and treating the cause of thyrotoxicosis, since maintaining a euthyroid state will prevent further episodes of TPP.
甲状腺毒症性周期性瘫痪（TPP）是一种罕见的肌肉疾病，其特征为甲状腺毒症引发的肌无力和低钾血症。在亚洲人群中，2%的甲状腺毒症患者会受到影响，相比之下，非亚洲人群中仅有0.1 - 0.2%受影响。绝大多数患者为男性。肌无力的严重程度从非常轻微到危及生命不等，这是由于呼吸功能受损所致。我们报告一例既往健康的39岁西班牙裔男性病例，该患者出现突发四肢瘫，在接受低钾血症和甲状腺毒症治疗后迅速康复。TPP虽然不常见，但认识到它很重要，因为它是一种潜在致命疾病，需要密切监测，且通过适当治疗很容易逆转。任何导致甲状腺激素过多的原因都可引起TPP，其中格雷夫斯病是最常见的病因。急性治疗包括补充钾，而长期管理则侧重于确定并治疗甲状腺毒症的病因，因为维持甲状腺功能正常状态可预防TPP的进一步发作。
