Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois, USA.
Cincinnati Children's Hospital Medical Center Heart Institute, Cincinnati, Ohio, USA.
Pediatr Dermatol. 2021 Nov;38(6):1461-1474. doi: 10.1111/pde.14841. Epub 2021 Nov 1.
Cutaneous disease can often be an initial clue of an underlying cardiovascular disease. Many congenital conditions (ie, Noonan syndrome with multiple lentigines, Carney complex, and Fabry disease) and acquired conditions may present initially with specific cutaneous features that should prompt clinicians to conduct a full cardiac workup. Given the extensive number of conditions with both cardiovascular and cutaneous findings, this review will focus on diseases with cardiocutaneous pathology with hopes of raising clinician awareness of these associations to decrease morbidity and mortality, as several of these diseases often result in fatal outcomes.
皮肤疾病常常是潜在心血管疾病的初始线索。许多先天性疾病（如多发性痣的努南综合征、卡尼综合征和法布里病）和获得性疾病可能最初表现为特定的皮肤特征，这应促使临床医生进行全面的心脏检查。鉴于具有心血管和皮肤表现的疾病数量众多，本综述将重点介绍具有心脏皮肤病理学的疾病，希望提高临床医生对这些关联的认识，以降低发病率和死亡率，因为其中一些疾病常常导致致命后果。
