Lv Congcong, Guo Xiaoyan, Hou Yue, Liu Wei, Guo Yanli, Zhang Zixuan, Jin Yan, Li Baoxin
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.
ACS Appl Mater Interfaces. 2021 Nov 17;13(45):53787-53797. doi: 10.1021/acsami.1c14563. Epub 2021 Nov 2.
As most of the known systems are flashtype, long-lasting chemiluminescence (CL) emissions are extremely needed for the application of cold light sources, accurate CL quantitative analysis, and biological mapping. In this work, the flashtype system of luminol was altered to a long lasting CL system just because of the paper substrate. The Cu(II)-based organic complex was loaded on the paper surface, which can trigger luminol-HO to produce a long lasting CL emission for over 30 min. By using 1,10-phenanthroline-2,9-dicarboxylic acid (PDA) as the ligand, a hexacoordinated Cu(II)-based organic complex was synthesized by the simple freeze-drying method. It is interesting that the complex morphology can be controlled by adding different amounts of water in the synthesizing procedure. The complex with a certain size can be definitely trapped in the pores of the cellulose. Then, slow diffusion, which can be attributed to the long lasting CL emission, was produced. With the high catalytic activity of the complex, reactive oxygen species from HO was generated and was responsible for the high CL intensity. By using the paper substrate, the flash-type luminol system can be easily transferred to the long-duration CL system without any extra reagent. This long-lasting emission system was used for hydrogen sulfide detection by the CL imaging method. This paper-based sensor has great potential for CL imaging in the clinical field in the future.
由于大多数已知体系都是闪光型的，冷光源应用、准确的化学发光（CL）定量分析和生物成像极其需要持久的化学发光发射。在这项工作中，由于纸质基底，鲁米诺的闪光型体系转变为了持久的CL体系。基于铜（II）的有机配合物负载在纸表面，它能触发鲁米诺-H2O2产生持续超过30分钟的持久CL发射。通过使用1,10-菲咯啉-2,9-二羧酸（PDA）作为配体，通过简单的冷冻干燥法合成了一种六配位的基于铜（II）的有机配合物。有趣的是，在合成过程中通过添加不同量的水可以控制配合物的形态。一定尺寸的配合物能够确切地被困在纤维素的孔隙中。然后，产生了可归因于持久CL发射的缓慢扩散。由于配合物具有高催化活性，产生了来自H2O2的活性氧物种，这导致了高CL强度。通过使用纸质基底，无需任何额外试剂就能轻松地将闪光型鲁米诺体系转变为长时间的CL体系。这种持久发射体系通过CL成像方法用于硫化氢检测。这种基于纸的传感器在未来临床领域的CL成像方面具有巨大潜力。
