慢性粒细胞白血病患者C带阳性染色体区域的异态性

Heteromorphism of C-band positive chromosomal regions in CML patients.

作者信息

Adhvaryu S G, Dave B J, Trivedi A H, Jani K H, Vyas R C

出版信息

Cancer Genet Cytogenet. 1987 Jul;27(1):33-8. doi: 10.1016/0165-4608(87)90257-3.

Abstract

The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.

摘要

利用骨髓和外周血淋巴细胞培养，对44例慢性粒细胞白血病患者和44例对照者的1号、9号和16号染色体组成型异染色质的异质性进行了研究。与对照组相比，慢性粒细胞白血病患者的所有三对染色体的C带区域长度均显著增加，并且1号染色体同源染色体存在统计学上的显著差异。患者中倒位的频率也高于对照组。在9号染色体的任何一条同源染色体上发现了22号染色体长臂的随机易位。