异染色质变体及其与肿瘤的关联。I. 慢性和急性白血病。

Heterochromatic variants and their association with neoplasias. I. Chronic and acute leukemia.

作者信息

Labal de Vinuesa M, Larripa I, Mudry de Pargament M, Brieux de Salum S

出版信息

Cancer Genet Cytogenet. 1984 Dec;13(4):297-302. doi: 10.1016/0165-4608(84)90074-8.

Abstract

C-banding studies of the heteromorphism of chromosomes #1, #9, and #16 were performed in 120 leukemic patients: 56 with chronic myelocytic leukemia (CML), 45 with acute lymphoblastic leukemia (ALL), and 19 with acute nonlymphoblastic leukemia (ANLL). No differences were found among patients and controls with regard to sex. Our data showed a significant increase of polymorphism in chromosome #1 in the three neoplastic groups; the heterochromatic variant preferentially involved 1qh-, whereas there were no significant differences in heteromorphism in chromosomes #9 and #16.

摘要

对120例白血病患者进行了1号、9号和16号染色体异态性的C带研究：56例慢性粒细胞白血病（CML）、45例急性淋巴细胞白血病（ALL）和19例急性非淋巴细胞白血病（ANLL）。患者和对照在性别方面未发现差异。我们的数据显示，在三个肿瘤组中，1号染色体的多态性显著增加；异染色质变异主要涉及1qh-，而9号和16号染色体的异态性无显著差异。