Atkin N B, Brito-Babapulle V
Cancer Genet Cytogenet. 1985 Dec;18(4):325-31. doi: 10.1016/0165-4608(85)90154-2.
Evidence for a relationship between chromosome #1 heterochromatin polymorphisms and cancer has been reviewed. Eighty-four of 135 (62%) patients with epithelial malignancies were heteromorphic for C-band size compared with 38 of 107 (36%) controls (significant at the 0.1% level). However, only 33 of 67 (49%) patients with nonepithelial malignancies were heteromorphic (not significantly different from controls). Similarly, the incidence of partial inversions of the C-band region in one or both homologs was significantly greater than controls [28 of 107 (26%)] for patients with epithelial [66 of 135 (49%)] but not nonepithelial [25 of 67 (37%)] malignancies. However, when the presence of either or both size heteromorphism and inversions were assessed, the incidence was significantly higher in patients with nonepithelial [46 of 67 (69%), including 11 of 11 patients with leukemia or myeloproliferative disorders] as well as epithelial [112 of 135 (83%)] malignancies compared with controls [52 of 107 (49%)]. Forty-seven of the patients did not differ significantly from controls with respect to the incidence of chromosome #1 heteromorphism as revealed by the Giemsa-11 technique. However, 26 patients assessed for their chromosome #1 lateral asymmetry pattern differed significantly from controls, having a higher incidence of compound asymmetry with a large proximal and small distal block and a lower incidence of simple asymmetry.
关于1号染色体异染色质多态性与癌症之间关系的证据已被综述。135例上皮性恶性肿瘤患者中有84例（62%）C带大小呈异态，而107例对照中有38例（36%）（在0.1%水平上具有显著性差异）。然而，67例非上皮性恶性肿瘤患者中只有33例（49%）呈异态（与对照无显著差异）。同样，上皮性恶性肿瘤患者[135例中有66例（49%）]中一条或两条同源染色体C带区域部分倒位的发生率显著高于对照[107例中有28例（26%）]，而非上皮性恶性肿瘤患者[67例中有25例（37%）]则不然。然而，当评估大小异态和倒位中任一项或两项的存在情况时，非上皮性恶性肿瘤患者[67例中有46例（69%），包括11例白血病或骨髓增殖性疾病患者中的11例]以及上皮性恶性肿瘤患者[135例中有112例（83%）]的发生率显著高于对照[107例中有52例（49%）]。47例患者在吉姆萨-11技术显示的1号染色体异态发生率方面与对照无显著差异。然而，26例接受1号染色体侧向不对称模式评估的患者与对照有显著差异，复合不对称（近端大、远端小的块）发生率较高，简单不对称发生率较低。
