Department of Physics, NanoSystems Initiative Munich and Center for Nanoscience, Ludwig-Maximilians-Universität München, Amalienstrasse 54, 80799, Munich, Germany.
Tescan Brno s.r.o., Libušina třída 1, 62300, Brno, Czech Republic.
Chemistry. 2021 Dec 15;27(70):17581-17585. doi: 10.1002/chem.202103672. Epub 2021 Nov 23.
The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3',5'-cyclic guanosine monophosphate (3',5'-cGMP) has been proposed as a candidate to create oligonucleotides of 15-20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.
从核苷酸前体中组装古老的信息聚合物是地球上生命起源的核心挑战。在可能的解决方案中，3'，5'-环鸟苷一磷酸（3'，5'-cGMP）的干聚合已被提议作为生成 15-20 个核苷酸长度的寡核苷酸的候选物。然而，该反应对阳离子存在的敏感性已被报道，这使得人们对这种化学物质在地质背景下是否相关产生了疑问。本研究中的实验表明，只要反应在酸性环境中进行，阳离子的存在就不会受到限制，这与之前的报告形成对比，之前的报告表明最佳条件为 pH 值 9。
