Cruz-Cabeza Aurora J, Davey Roger J, Sachithananthan Sharlinda Salim, Smith Rebecca, Tang Sin Kim, Vetter Thomas, Xiao Yan
School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, UK.
Chem Commun (Camb). 2017 Jul 11;53(56):7905-7908. doi: 10.1039/c7cc02423a.
Crystal nucleation from solution is of central importance in the chemical and biological sciences. Linking nucleation kinetics to the properties of solutes and solvents remains a grand-challenge in physical chemistry. Through a unique dataset of compounds able to self-assemble via both hydrogen-bonds and aromatic stacking, we are able to compare the importance of these two types of interaction in driving the nucleation process. Contrary to previous reports in which solution chemistry and hydrogen bonding have been seen as controlling factors, we are now able to show that cluster growth via aromatic stacking holds the key.
从溶液中形成晶体核在化学和生物科学中至关重要。将成核动力学与溶质和溶剂的性质联系起来仍然是物理化学中的一个重大挑战。通过一个独特的化合物数据集，这些化合物能够通过氢键和芳香堆积进行自组装，我们能够比较这两种相互作用在驱动成核过程中的重要性。与之前将溶液化学和氢键视为控制因素的报道相反，我们现在能够表明通过芳香堆积的簇生长是关键。
