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使用EuraHS-QoL评分评估开放腹股沟疝修补术后生活质量低下的预测因素:一项在33家医院开展的前瞻性多中心队列研究

Predictors of low quality of life after open inguinal hernia repair using the EuraHS-QoL score: prospective multicentric cohort study across 33 hospitals.

出版信息

Hernia. 2022 Feb;26(1):225-232. doi: 10.1007/s10029-021-02498-2. Epub 2021 Nov 2.

DOI:10.1007/s10029-021-02498-2
PMID:34727286
Abstract

PURPOSE

Evidence about factors influencing quality of life after inguinal hernia surgery is scarce. This study aimed to assess patient's Quality of Life (QoL) after open inguinal hernia repair and to identify predictors of low QoL at 3 months after surgery, to guide practice and inform patients at high risk.

METHODS

Prospective multicentric cohort study including consecutive patients undergoing elective open inguinal hernia repair in Portuguese hospitals (October-December 2019). The primary outcome was Quality of Life at 3 months after surgery, using the EuraHS-QoL score (higher score correlates with lower QoL). Low QoL was defined as the higher EuraHS-QoL score tertile and multivariate logistic regression was used to identify predictors.

RESULTS

893 patients were included from 33 hospitals. The majority were men [89.9% (800/891)], had unilateral hernias 88.7% (774/872) and the most common surgical technique was Lichtenstein's repair [52.9% (472/893)]. The median QoL score was 24 (IQR 10-40) before surgery and 2 (IQR 0-10) at 3 months after surgery, showing significant improvement (p < 0.001). After adjustment, low QoL at 3 months was associated with low preoperative QoL (OR 1.76, 95% CI 1.21-2.57, p = 0.003), non-absorbable mesh fixation (OR 1.64, 95% CI 1.12-2.41, p = 0.011), severe immediate postoperative pain (OR 2.90, 95% CI 1.66-5.11, p < 0.001) and minor postoperative complications (OR 2.23, 95% CI 1.30-3.84, p = 0.004).

CONCLUSION

This study supports the use of the EuraHS-QoL score preoperatively to inform consent. Although significant improvement in QoL is expected after surgery, high scores before surgery are associated with low postoperative QoL. Caution should be taken with non-absorbable mesh fixation and immediate postoperative pain control should be optimised.

摘要

目的

关于影响腹股沟疝修补术后生活质量因素的证据匮乏。本研究旨在评估开放腹股沟疝修补术后患者的生活质量(QoL),并确定术后3个月生活质量低下的预测因素,以指导临床实践并告知高危患者。

方法

前瞻性多中心队列研究,纳入葡萄牙医院连续接受择期开放腹股沟疝修补术的患者(2019年10月至12月)。主要结局指标为术后3个月的生活质量,采用EuraHS-QoL评分(分数越高,生活质量越低)。生活质量低下定义为EuraHS-QoL评分处于较高三分位数,采用多因素逻辑回归分析确定预测因素。

结果

来自33家医院的893例患者纳入研究。大多数为男性[89.9%(800/891)],单侧疝占88.7%(774/872),最常用的手术技术是Lichtenstein修补术[52.9%(472/893)]。术前生活质量评分中位数为24(四分位间距10-40),术后3个月为2(四分位间距0-10),显示出显著改善(p<0.001)。调整后,术后3个月生活质量低下与术前生活质量低下相关(比值比1.76,95%置信区间1.21-2.57,p=0.003)、不可吸收补片固定(比值比1.64,95%置信区间1.12-2.41,p=0.011)、术后即刻严重疼痛(比值比2.90,95%置信区间1.66-5.11,p<0.001)和术后轻微并发症(比值比2.23,95%置信区间1.30-3.84,p=0.004)有关。

结论

本研究支持术前使用EuraHS-QoL评分以进行知情同意告知。虽然术后生活质量有望显著改善,但术前评分高与术后生活质量低下相关。应谨慎使用不可吸收补片固定,并优化术后即刻疼痛控制。

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