Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, 200433, China.
School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai, 200092, China.
Ann Nucl Med. 2022 Jan;36(1):1-14. doi: 10.1007/s12149-021-01683-8. Epub 2021 Nov 2.
With a 5-year overall survival of approximately 20%, lung cancer has always been the number one cancer-specific killer all over the world. As a fusion of positron emission computed tomography (PET) and computed tomography (CT), PET/CT has revolutionized cancer imaging over the past 20 years. In this review, we focused on the optimization of the function of F-flurodeoxyglucose (FDG)-PET/CT in diagnosis, prognostic prediction and therapy management of lung cancers by computer programs. FDG-PET/CT has demonstrated a surprising role in development of therapeutic biomarkers, prediction of therapeutic responses and long-term survival, which could be conducive to solving existing dilemmas. Meanwhile, novel tracers and optimized procedures are also developed to control the quality and improve the effect of PET/CT. With the continuous development of some new imaging agents and their clinical applications, application value of PET/CT has broad prospects in this area.
肺癌的总生存期约为 5 年，全球范围内一直是癌症特异性死亡的首要原因。正电子发射断层扫描（PET）和计算机断层扫描（CT）的融合使 PET/CT 在过去 20 年中彻底改变了癌症成像。在这篇综述中，我们专注于通过计算机程序优化 F-氟脱氧葡萄糖（FDG）-PET/CT 在肺癌诊断、预后预测和治疗管理中的功能。FDG-PET/CT 在治疗生物标志物的发展、治疗反应和长期生存的预测方面显示出令人惊讶的作用，这有助于解决现有困境。同时，还开发了新型示踪剂和优化程序来控制质量并提高 PET/CT 的效果。随着一些新型成像剂及其临床应用的不断发展，PET/CT 的应用价值在这一领域具有广阔的前景。
