Department of Chemistry, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland.
Department of Chemistry, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland;, Email:
Chimia (Aarau). 2021 Oct 27;75(10):837-844. doi: 10.2533/chimia.2021.837.
Luminescent rhenium complexes continue to be the focus of growing scientific interest for catalytic, diagnostic and therapeutic applications, with emphasis on the development of their photophysical and photochemical properties. In this short review, we explore such properties with a focus on the biological applications of the molecules. We discuss the importance of the ligand choice to the contribution and their involvement towards the most significant electronic transitions of the metal species and what strategies are used to exploit the potential of the molecules in medicinal applications. We begin by detailing the photophysics of the molecules; we then describe the three most common photoreactions of rhenium complexes as photosensitizers in H₂ production, photocatalysts in CO₂ reduction and photochemical ligand substitution. In the last part, we describe their applications as luminescent cellular probes and how photochemical ligand substitution is utilized in the development of photoactive carbon monoxide-releasing molecules as anticancer and antimicrobial agents.
发光铼配合物继续成为催化、诊断和治疗应用中越来越受到关注的科学焦点，重点是开发它们的光物理和光化学性质。在这篇简短的综述中，我们探讨了这些性质，重点是分子的生物学应用。我们讨论了配体选择对金属物种最重要的电子跃迁的贡献及其参与的重要性，以及为了开发分子在药物应用中的潜力而采用的策略。我们首先详细描述了分子的光物理性质；然后描述了铼配合物作为 H₂ 产生的光敏剂、CO₂ 还原的光催化剂和光化学配体取代的三种最常见的光反应。在最后一部分，我们描述了它们作为发光细胞探针的应用，以及光化学配体取代如何用于开发作为抗癌和抗菌剂的光活性一氧化碳释放分子。
