Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P.R. China.
Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503-1511, 15/F, Building 17W, Hong Kong Science Park, New Territories, Hong Kong, P.R. China.
J Am Chem Soc. 2022 Aug 17;144(32):14420-14440. doi: 10.1021/jacs.2c03437. Epub 2022 Aug 4.
There has been emerging interest in the exploitation of the photophysical and photochemical properties of transition metal complexes for diagnostic and therapeutic applications. In this Perspective, we highlight the major recent advances in the development of luminescent and photofunctional transition metal complexes, in particular, those of rhenium(I), ruthenium(II), osmium(II), iridium(III), and platinum(II), as bioimaging reagents and phototherapeutic agents, with a focus on the molecular design strategies that harness and modulate the interesting photophysical and photochemical behavior of the complexes. We also discuss the current challenges and future outlook of transition metal complexes for both fundamental research and clinical applications.
人们对利用过渡金属配合物的光物理和光化学性质来进行诊断和治疗应用越来越感兴趣。在本观点文章中，我们重点介绍了开发发光和光功能过渡金属配合物的主要最新进展，特别是铼（I）、钌（II）、锇（II）、铱（III）和铂（II）配合物作为生物成像试剂和光疗剂的进展，重点讨论了利用和调节配合物有趣的光物理和光化学行为的分子设计策略。我们还讨论了过渡金属配合物在基础研究和临床应用方面的当前挑战和未来展望。
