'(m)A' 代表 '自身免疫': 在炎症期间读写和擦除 RNA 修饰。
'(m)A' stands for 'autoimmunity': reading, writing, and erasing RNA modifications during inflammation.
机构信息
Université Paris-Saclay, CEA, INSERM UMR 1184, Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto-Immunes, Le Kremlin Bicêtre, France.
Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Trends Immunol. 2021 Dec;42(12):1073-1076. doi: 10.1016/j.it.2021.10.002. Epub 2021 Oct 30.
Abstract
Covalent RNA modifications that regulate gene expression post transcriptionally, in particular N6-methyladenosine (mA), are emerging as important regulators of autoimmune responses. Here, we highlight new findings describing the functional diversity and specificity of mA modifications and their regulation in the context of autoimmunity.
摘要
共价 RNA 修饰可在后转录水平调节基因表达，特别是 N6-甲基腺苷（m6A），它们正在成为自身免疫反应的重要调节因子。在这里，我们重点介绍了新的发现，描述了 m6A 修饰在自身免疫中的功能多样性和特异性及其调控。
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