School of Psychology and Cognitive Science, East China Normal University, Shanghai, PR China.
Shaanxi Key Laboratory of Behavior and Cognitive Neuroscience, School of Psychology, Shaanxi Normal University, Xi'an, PR China.
Brain Res Bull. 2022 Jan;178:49-56. doi: 10.1016/j.brainresbull.2021.10.019. Epub 2021 Oct 30.
Internet gaming disorder (IGD) has become an increasing mental health issue worldwide. Previous studies indicated that IGD was related to maladaptive risk-taking behavior. However, the relationship among risk-taking behavior, reflection level, and resting-state functional connectivity (rsFC) between brain regions in IGD individuals remains unclear. The current study combined resting-state fMRI and the Devil task to investigate this issue. The behavioral results suggested that IGD participants exhibited increased risk-taking behavior in the Devil task than healthy controls. Moreover, IGD participants' risk-taking behavior was positively correlated with their reflection level. As for fMRI results, IGD participants showed stronger rsFC between orbitofrontal cortex (OFC) and inferior frontal gyrus (IFG) than healthy controls. Additionally, the mediation analyses revealed that, among IGD participants, the rsFC between OFC and IFG fully mediated the relationship between reflection level and risk-taking behavior. Together, the current study highlighted that the altered rsFC between OFC and IFG in IGD individuals modified the relationship between their reflection level and risk-taking behavior, which might contribute to the understanding of neural mechanisms underlying risk-taking behavior in IGD individuals.
网络成瘾障碍（IGD）已成为全球日益严重的心理健康问题。先前的研究表明，IGD 与适应不良的冒险行为有关。然而，IGD 个体中冒险行为、反思水平和大脑区域静息态功能连接（rsFC）之间的关系尚不清楚。本研究结合静息态功能磁共振成像和魔鬼任务来研究这个问题。行为结果表明，IGD 参与者在魔鬼任务中的冒险行为比健康对照组更高。此外，IGD 参与者的冒险行为与其反思水平呈正相关。对于 fMRI 结果，IGD 参与者的眶额皮层（OFC）和额下回（IFG）之间的 rsFC 强于健康对照组。此外，中介分析表明，在 IGD 参与者中，OFC 和 IFG 之间的 rsFC 完全介导了反思水平和冒险行为之间的关系。综上所述，本研究强调了 IGD 个体中眶额皮层和额下回之间改变的 rsFC 改变了他们的反思水平和冒险行为之间的关系，这可能有助于理解 IGD 个体冒险行为的神经机制。
