Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Institute of Psychological Science, Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Addict Biol. 2021 Jul;26(4):e12985. doi: 10.1111/adb.12985. Epub 2020 Nov 24.
Cognitive, functional, and structural brain factors involving frontal executive and striatal reward networks have been implicated in Internet gaming disorder (IGD). However, frontostriatal network connectivity and its association with addiction severity are poorly understood in IGD. Resting-state fMRI data from 337 subjects (130 with IGD, 207 with recreational game use [RGU]) were collected. Striatal-cortical communications were measured with resting-state functional connectivity (FC) using coherent spontaneous fluctuations in the blood-oxygenation-level-dependent fMRI signal. Correlations were calculated between FC measures and IGD-related assessments (addiction severity and craving scores). Decreased FC was predominantly observed in IGD subjects, with IGD subjects showing decreased FC between the putamen and superior frontal gyrus (SFG), middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) and the ventral striatum and IFG, superior temporal gyrus, and MFG. Disorder severity and craving scores were negatively correlated with FC between striatal and frontal brain regions. Associations between diminished FC in corticostriatal circuitry and clinical features (IGD craving, severity) suggest potential therapeutic targets for neuromodulation treatments. The extent to which frontostriatal circuits involving executive control over reward processes may be altered to treat IGD warrants additional study.
认知、功能和结构脑因素涉及额执行和纹状体奖励网络，与网络成瘾障碍（IGD）有关。然而，IGD 中额纹状体网络连接及其与成瘾严重程度的关系尚不清楚。从 337 名受试者（130 名患有 IGD，207 名有娱乐性游戏使用 [RGU]）中收集了静息状态 fMRI 数据。使用血氧水平依赖 fMRI 信号的相干自发波动，通过静息状态功能连接（FC）测量纹状体 - 皮质通讯。在成瘾严重程度和渴望评分之间，计算了 FC 测量值之间的相关性。IGD 受试者主要表现为 FC 减少，IGD 受试者纹状体和额上回（SFG）、额中回（MFG）和额下回（IFG）之间以及纹状体和 IFG、颞上回和 MFG 之间的 FC 减少。疾病严重程度和渴望评分与纹状体和额叶脑区之间的 FC 呈负相关。皮质纹状体电路中 FC 减少与临床特征（IGD 渴望、严重程度）之间的关联表明神经调节治疗的潜在治疗靶点。涉及奖励过程的额纹状体回路改变的程度可能会改变以治疗 IGD，值得进一步研究。
