Department of Separation Science, LUT School of Engineering Science, LUT University, Sammonkatu 12, FI-50130, Mikkeli, Finland.
Enviromicrobiology, Ecotoxicology and Ecotechnology Research Laboratory, Department of Ecological Studies, University of Kalyani, Kalyani, Nadia 741235, West Bengal, India; International Centre for Ecological Engineering, University of Kalyani, Kalyani 741235, West Bengal, India.
Bioresour Technol. 2022 Jan;344(Pt B):126250. doi: 10.1016/j.biortech.2021.126250. Epub 2021 Oct 30.
The myriad health benefits associated with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) laid the path for their application in the functional foods and nutraceutical industries. Fish being primarily exploited for extraction of EPA and DHA are unsustainable sources; thus, oleaginous microalgae turn out to be an alternative sustainable source. This review paper aims to provide the recent developments in the context of enhancing EPA and DHA production by utilising non-genetic tailoring and genetic tailoring methods. We have also summarized the legislation, public perception, and possible risks associated with the usage of genetically modified microalgae focusing on EPA and DHA production.
二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)与众多健康益处相关,这为它们在功能性食品和营养保健品行业的应用铺平了道路。鱼类是提取 EPA 和 DHA 的主要来源,但这种方式不可持续;因此,油脂微藻成为一种替代的可持续来源。本文旨在提供利用非遗传修饰和遗传修饰方法提高 EPA 和 DHA 产量的最新进展。本文还总结了与使用基因修饰微藻生产 EPA 和 DHA 相关的立法、公众认知和可能存在的风险。