儿童创伤性脑损伤后创伤后癫痫的发生率：系统评价和荟萃分析方案。
Incidence of post-traumatic epilepsy following paediatric traumatic brain injury: protocol for systematic review and meta-analysis.
机构信息
Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Department of Neurology, Alfred Health, Prahran, Victoria, Australia.
出版信息
BMJ Open. 2021 Nov 2;11(11):e054034. doi: 10.1136/bmjopen-2021-054034.
INTRODUCTION
Post-traumatic epilepsy (PTE) is a recognised complication of traumatic brain injury (TBI), and is associated with higher rates of mortality and morbidity when compared with patients with TBI who do not develop PTE. The majority of the literature on PTE has focused on adult populations, and consequently there is a paucity of information regarding paediatric cohorts. Additionally, there is considerable heterogeneity surrounding the reported incidence of PTE following childhood TBI in the current literature. The primary aim of our study is to summarise reported PTE incidences in paediatric populations to derive an accurate estimate of the global incidence of PTE following childhood TBI. Our secondary aim is to explore risk factors that increase the likelihood of developing PTE.
METHODS AND ANALYSIS
A systematic literature search of Embase (1947-2021), PubMed (1996-2021) and Web of Science (1900-2021) will be conducted. Publications in English that report the incidence of PTE in populations under 18 years of age will be included. Publications that evaluate fewer than 10 patients, report an alternative cause of epilepsy, or in which a paediatric cohort is not discernable, will be excluded. Independent investigators will identify the relevant publications, and discrepancies will be adjudicated by a third independent investigator. Data extracted will include incidence of PTE, time intervals between TBI and PTE, seizure characteristics, injury characteristics, patient demographics and clinical data. Data extraction will be performed by two independent investigators and cross-checked by a third investigator. A descriptive analysis of PTE incidence will be conducted and a weighted mean will be calculated. If sufficient data are available, stratified meta-analysis of subgroups will also be conducted.
ETHICS AND DISSEMINATION
Ethics approval was not required for this study. We intend to publish our findings in a high-quality peer-reviewed journal on completion.
PROSPERO REGISTRATION NUMBER
CRD42021245802.
简介
创伤后癫痫（PTE）是创伤性脑损伤（TBI）的一种公认并发症，与未发生 PTE 的 TBI 患者相比，其死亡率和发病率更高。大多数关于 PTE 的文献都集中在成年人群体上，因此关于儿科患者的数据很少。此外，目前文献中关于儿童 TBI 后 PTE 发生率的报道存在很大的异质性。我们的主要研究目的是总结儿科人群中报告的 PTE 发生率，以得出儿童 TBI 后 PTE 的全球准确发生率估计。我们的次要目的是探讨增加发生 PTE 可能性的风险因素。
方法和分析
我们将对 Embase（1947 年至 2021 年）、PubMed（1996 年至 2021 年）和 Web of Science（1900 年至 2021 年）进行系统的文献检索。纳入报告 18 岁以下人群中 PTE 发生率的英文出版物。将排除评估患者少于 10 例、报告其他癫痫病因或无法识别儿科患者的出版物。独立调查人员将确定相关出版物，如果存在分歧，将由第三位独立调查人员进行裁决。提取的数据将包括 PTE 的发生率、TBI 与 PTE 之间的时间间隔、癫痫发作特征、损伤特征、患者人口统计学和临床数据。数据提取将由两名独立调查人员进行，并由第三名调查人员进行交叉检查。将对 PTE 发生率进行描述性分析，并计算加权平均值。如果有足够的数据，还将对亚组进行分层荟萃分析。
伦理和传播
本研究无需伦理批准。完成后，我们打算在高质量的同行评审期刊上发表我们的研究结果。
PROSPERO 注册号：CRD42021245802。
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