Department of Morphology and the Institute of Biomedicine, School of Medicine (F.V.G.J., G.A.M., J.d.S.R.C., C.R.R., R.B.O.) and Department of Organic and Inorganic Chemistry (E.M.C., L.G.d.F.L.), Federal University of Ceará, Fortaleza, Brazil; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana (L.B.); and Laboratory of Experimental Vascular Surgery and Gene Expression, School of Medicine, Christus University Center (UNICHRISTUS), Fortaleza, Brazil (M.W.S.C.).
Department of Morphology and the Institute of Biomedicine, School of Medicine (F.V.G.J., G.A.M., J.d.S.R.C., C.R.R., R.B.O.) and Department of Organic and Inorganic Chemistry (E.M.C., L.G.d.F.L.), Federal University of Ceará, Fortaleza, Brazil; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana (L.B.); and Laboratory of Experimental Vascular Surgery and Gene Expression, School of Medicine, Christus University Center (UNICHRISTUS), Fortaleza, Brazil (M.W.S.C.)
J Pharmacol Exp Ther. 2022 Jan;380(1):47-53. doi: 10.1124/jpet.121.000798. Epub 2021 Nov 2.
Ruthenium compounds, nitric oxide donors in biologic systems, have emerged as a promising therapeutic alternative to conventional drugs in anticancer chemotherapy and as a potential neuroprotective agent with fewer cytotoxic effects. This minireview summarizes promising studies with ruthenium complexes and their roles in cancer, neuroinflammation, neurovascular, and neurodegenerative diseases. The up-to-date evidence supports that ruthenium-based compounds have beneficial effects against gliomas and other types of brain cancers, reduce motor symptoms in models of cerebral ischemia-reperfusion, and may act in the control of nociceptive and inflammatory events, such as those seen in early Alzheimer's disease. More studies are needed to fill many current knowledge gaps about the intricate and complex biologic effects and therapeutic-related mechanisms of ruthenium, stimulating further research. SIGNIFICANCE STATEMENT: This minireview summarizes studies addressing the role of ruthenium compounds on neurological illnesses, focusing on brain cancer and neurovascular and neurodegenerative diseases. No such review is available in the literature.
钌化合物是生物体系中的一氧化氮供体，已成为癌症化学治疗中传统药物的一种很有前途的治疗替代物，也是一种潜在的神经保护剂，其细胞毒性作用较小。这篇综述总结了有关钌配合物的有前途的研究及其在癌症、神经炎症、神经血管和神经退行性疾病中的作用。最新证据表明，基于钌的化合物对神经胶质瘤和其他类型的脑癌有有益的作用，可减少脑缺血再灌注模型中的运动症状，并可能控制疼痛和炎症等事件，如在早期阿尔茨海默病中所见。需要更多的研究来填补关于钌的复杂生物效应和治疗相关机制的许多当前知识空白，这将刺激进一步的研究。意义陈述：这篇综述总结了有关钌化合物在神经疾病中的作用的研究，重点是脑癌和神经血管及神经退行性疾病。文献中尚无此类综述。
