靶向脑胶质瘤：钌类药物的疗效。
Targeting Glioblastoma: Efficacy of Ruthenium-Based Drugs.
机构信息
Center for Nonlinear Systems, Chennai Institute of Technology (CIT), Chennai 600069, India.
Department of Chemistry, National Institute of Technology, Tiruchirappalli, Tamil Nadu 620015, India.
出版信息
Chem Res Toxicol. 2024 Sep 16;37(9):1453-1455. doi: 10.1021/acs.chemrestox.4c00188. Epub 2024 Aug 20.
Abstract
Ruthenium compounds offer improved selectivity and fewer side effects compared to platinum-based drugs in glioblastoma treatment. Insights into their interactions with transferrin suggest targeted drug delivery, while photoactivated chemotherapy is a novel cytotoxic approach in tumor tissues.
摘要
钌化合物在治疗脑胶质母细胞瘤方面比铂类药物具有更高的选择性和更少的副作用。对它们与转铁蛋白相互作用的深入了解表明可以进行靶向药物递送，而光激活化疗是肿瘤组织中一种新的细胞毒性方法。
Zotero 插件