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一种用于兽医肿瘤学应用的高强度聚焦超声系统。

A High Intensity Focused Ultrasound System for Veterinary Oncology Applications.

作者信息

Spanoudes Kyriakos, Evripidou Nikolas, Giannakou Marinos, Drakos Theocharis, Menikou George, Damianou Christakis

机构信息

Department of Electrical Engineering, Cyprus University of Technology, Limassol, Cyprus.

Vet Ex Machina Ltd., Nicosia, Cyprus.

出版信息

J Med Ultrasound. 2021 May 4;29(3):195-202. doi: 10.4103/JMU.JMU_130_20. eCollection 2021 Jul-Sep.

Abstract

BACKGROUND

Magnetic resonance-guided focused ultrasound surgery is an incisionless energy-based thermal method that is used for ablating tumors in the veterinary clinic.

AIMS AND OBJECTIVES

In this article we describe a prototype of a veterinary system compatible with magnetic resonance imaging intended for small-to-medium-sized companion animals that was developed and tested in adult rabbits.

METHODS

Real-time monitoring of the ablation during the experiment was possible with MR thermometry. Experiments involved thermal monitoring of sonications applied in the thigh of the rabbits. A 38-mm diameter transducer operating at 2.6 MHz was used with a 60-mm-focal length. The robotic system employed 3 linear axes and one angular axis. For this study, only X and Y axis were enabled. Due to the target size limitations, motion in Z and Θ was not needed. The functionality of the positioning device was evaluated by means of MR thermometry, demonstrating sufficient heating and accurate motion in both axes of operation.

RESULTS

The postmortem findings confirm the ability of the system to induce thermal ablations in the absence of adverse effects.

CONCLUSIONS

The device is a reliable and affordable solution for companion animal hospitals, offering and additional tool for the veterinary oncology society.

摘要

背景

磁共振引导聚焦超声手术是一种基于能量的无切口热疗方法,用于兽医临床肿瘤消融。

目的

在本文中,我们描述了一种适用于中小型伴侣动物的、与磁共振成像兼容的兽医系统原型,该原型已在成年兔身上进行了开发和测试。

方法

实验过程中通过磁共振测温法对消融进行实时监测。实验包括对兔大腿进行超声处理的热监测。使用了一个直径38毫米、工作频率为2.6兆赫、焦距为60毫米的换能器。机器人系统采用3个线性轴和1个角轴。在本研究中,仅启用了X轴和Y轴。由于目标尺寸限制,不需要Z轴和Θ轴的运动。通过磁共振测温法评估了定位装置的功能,结果表明在两个操作轴上均有足够的加热和精确的运动。

结果

尸检结果证实该系统能够在无不良反应的情况下诱导热消融。

结论

该设备为伴侣动物医院提供了一种可靠且经济实惠的解决方案,为兽医肿瘤学界提供了一种额外的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c077/8515634/8c1b8cb9ed6b/JMU-29-195-g001.jpg

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