Wintler Taylor, Zherebtsov Monica, Carmack Susanne, Muntean Rebecca, Hill Sarah J
Washington State University, Elson S. Floyd College of Medicine, Spokane, WA, USA.
Pediatric Gastroenterology Providence Digestive Health Institute, Spokane, WA, USA.
J Pediatr Surg Case Rep. 2021 Dec;75:102103. doi: 10.1016/j.epsc.2021.102103. Epub 2021 Oct 29.
We present the case of an acute onset ANCA positive vasculitis in an asymptomatic COVID-19 infected teenager, resulting in significant colonic damage. The patient was initially diagnosed with Henoch-Schönlein purpura and presented with worsening symptoms with significant necrosis of her perineum and rectum requiring surgical debridement and diverting colostomy. As a part of her work-up, she tested positive for COVID-19 total IgG/IgM antibodies and ANCA antibodies. This case complements previously reported cases of COVID-19 induced autoimmune disease in children but is novel in describing extensive intestinal disease as a result of an autoimmune vasculitis in a child.
我们报告了一例无症状的新冠病毒感染青少年急性起病的抗中性粒细胞胞浆抗体（ANCA）阳性血管炎病例，该病例导致了严重的结肠损伤。患者最初被诊断为过敏性紫癜，随后症状加重，会阴和直肠出现严重坏死，需要进行手术清创和结肠造口术。在检查过程中，她的新冠病毒总IgG/IgM抗体和ANCA抗体检测呈阳性。该病例补充了先前报道的儿童新冠病毒诱导的自身免疫性疾病病例，但在描述儿童自身免疫性血管炎导致广泛肠道疾病方面具有新颖性。
