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波特氏截瘫与神经影像学在资源有限环境中的作用:一例病例报告及文献简要综述

Pott's paraplegia and role of neuroimaging in resource limited setting: A case report and brief review of the literatures.

作者信息

Ayele Biniyam A, Wako Abdinasir, Tadesse Jarso, Gulelat Hildana, Ibrahim Riyad, Molla Sisay, Bati Abdi

机构信息

Department of Neurology, Addis Ababa University, Addis Ababa, Ethiopia.

School of Medicine, Jijiga University, Jijiga, Ethiopia.

出版信息

J Clin Tuberc Other Mycobact Dis. 2021 Oct 19;25:100283. doi: 10.1016/j.jctube.2021.100283. eCollection 2021 Dec.

Abstract

BACKGROUND

Tuberculosis (TB) is the leading cause of morbidity and mortality in low and middle income countries (LMIC). Approximately 50% of cases of skeletal TB involve the spine. Failure to identify and treat these areas of involvement at an early stage may lead to serious complications such as vertebral collapse, spinal compression, and spinal deformity. The clinical and radiologic features of Pott's disease may mimic other spine diseases such as, metastatic lesions and other infectious etiologies, this is especially imperative in older patients.

CASE REPORT

We report a 60-year-old right handed male patient presented with back pain, paraparesis, and sensory symptoms 2 weeks duration. He has history of dry cough, fatigue, and reduced appetite, but no history of weight loss, fever, night sweat, and bowel/bladder incontinence. No contact history with TB patients. He has a borderline hypertension and diabetes mellitus. Serology for HIV was negative. Thoraco-lumbar magnetic resonance image (MRI) showed destruction of L2 and L3 vertebral body and the inter-vertebral disc; with T2 hyper and T1 hypointensity of the affected vertebral bodies. Probable tuberculous spondylitis with paraparesis was considered and the patient was initiated on antituberculous regimen and short course steroid therapy. After five months treatment, the patient showed significant clinical and radiological improvement.

CONCLUSION

In summary, the present case describes, a patient with Pott's paraplegia due to probable spine tuberculosis and showed significant clinical and radiological improvement following initiation of antituberculous drugs and short course of steroid; indicating the crucial role of imaging in the diagnosis of TB, especially in resource limited settings.

摘要

背景

结核病是低收入和中等收入国家发病和死亡的主要原因。约50%的骨结核病例累及脊柱。未能在早期识别和治疗这些受累部位可能导致严重并发症,如椎体塌陷、脊髓受压和脊柱畸形。脊柱结核的临床和放射学特征可能与其他脊柱疾病相似,如转移性病变和其他感染性病因,这在老年患者中尤为重要。

病例报告

我们报告一名60岁右利手男性患者,出现背痛、双下肢轻瘫和感觉症状,持续2周。他有干咳、疲劳和食欲减退史,但无体重减轻、发热、盗汗和大小便失禁史。无结核病患者接触史。他患有临界高血压和糖尿病。HIV血清学检查为阴性。胸腰椎磁共振成像(MRI)显示L2和L3椎体及椎间盘破坏;受累椎体T2加权像高信号、T1加权像低信号。考虑可能为结核性脊柱炎伴双下肢轻瘫,遂开始给予抗结核治疗方案及短程激素治疗。治疗五个月后,患者临床和影像学均有显著改善。

结论

总之,本病例描述了一名可能因脊柱结核导致截瘫的患者,在开始抗结核药物治疗和短程激素治疗后,临床和影像学均有显著改善;表明影像学在结核病诊断中起着关键作用,尤其是在资源有限的环境中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0e0/8546414/6b7f2bcc25e0/gr1.jpg

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