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射血分数保留的心力衰竭患者的多模态成像:欧洲心血管影像协会专家共识文件

Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging.

作者信息

Smiseth Otto A, Morris Daniel A, Cardim Nuno, Cikes Maja, Delgado Victoria, Donal Erwan, Flachskampf Frank A, Galderisi Maurizio, Gerber Bernhard L, Gimelli Alessia, Klein Allan L, Knuuti Juhani, Lancellotti Patrizio, Mascherbauer Julia, Milicic Davor, Seferovic Petar, Solomon Scott, Edvardsen Thor, Popescu Bogdan A

机构信息

Department of Cardiology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway.

Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway.

出版信息

Eur Heart J Cardiovasc Imaging. 2022 Jan 24;23(2):e34-e61. doi: 10.1093/ehjci/jeab154.

Abstract

Nearly half of all patients with heart failure (HF) have a normal left ventricular (LV) ejection fraction (EF) and the condition is termed heart failure with preserved ejection fraction (HFpEF). It is assumed that in these patients HF is due primarily to LV diastolic dysfunction. The prognosis in HFpEF is almost as severe as in HF with reduced EF (HFrEF). In contrast to HFrEF where drugs and devices are proven to reduce mortality, in HFpEF there has been limited therapy available with documented effects on prognosis. This may reflect that HFpEF encompasses a wide range of different pathological processes, which multimodality imaging is well placed to differentiate. Progress in developing therapies for HFpEF has been hampered by a lack of uniform diagnostic criteria. The present expert consensus document from the European Association of Cardiovascular Imaging (EACVI) provides recommendations regarding how to determine elevated LV filling pressure in the setting of suspected HFpEF and how to use multimodality imaging to determine specific aetiologies in patients with HFpEF.

摘要

近半数心力衰竭(HF)患者的左心室(LV)射血分数(EF)正常,这种情况被称为射血分数保留的心力衰竭(HFpEF)。据推测,在这些患者中,心力衰竭主要是由于左心室舒张功能障碍所致。HFpEF的预后几乎与射血分数降低的心力衰竭(HFrEF)一样严重。与已证实药物和器械可降低死亡率的HFrEF不同,HFpEF可用的治疗方法有限,且对预后有记录的影响。这可能反映出HFpEF涵盖了广泛的不同病理过程,而多模态成像非常适合区分这些过程。缺乏统一的诊断标准阻碍了HFpEF治疗方法的发展。欧洲心血管影像协会(EACVI)的这份专家共识文件就如何在疑似HFpEF的情况下确定左心室充盈压升高以及如何使用多模态成像来确定HFpEF患者的具体病因提供了建议。

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