Schmidt Ina, Albert Jacob, Ritthaler Marina, Papastavrou Areti, Steinmann Paul
Faculty of Mechanical Engineering, Nuremberg Tech, Nuremberg, Germany.
Institute of Applied Mechanics, University of Erlangen-Nuremberg, Erlangen, Germany.
Comput Methods Biomech Biomed Engin. 2022 Jul;25(9):1040-1050. doi: 10.1080/10255842.2021.1998465. Epub 2021 Nov 3.
Bone fracture healing is a complex process which is still under research. Computer-aided patient-specific prediction of bone development, fracture risk, prevention and treatment approaches promises a significant milestone in clinical practice. With this long-term goal in mind, a novel model is presented and examined in this work in the context of continuum bone remodelling. Therein, a clear distinction is made between external mechanical stimulation and the biological healing process of an injured bone tissue. The model is implemented within a finite element framework and investigated for the example of a fractured proximal femur head. The results show promising perspectives for further application. Besides, the model offers the possibility of easily integrating other factors like age-dependency and the availability of nutrition. For the future, further studies with large clinical datasets are essential for validation.
骨折愈合是一个仍在研究中的复杂过程。计算机辅助的针对特定患者的骨发育、骨折风险、预防和治疗方法的预测有望成为临床实践中的一个重要里程碑。出于这一长期目标,本文在连续骨重塑的背景下提出并检验了一种新模型。其中,明确区分了外部机械刺激和受伤骨组织的生物愈合过程。该模型在有限元框架内实现,并以近端股骨头骨折为例进行研究。结果显示了进一步应用的良好前景。此外,该模型还提供了轻松整合其他因素(如年龄依赖性和营养可用性)的可能性。未来,使用大型临床数据集进行进一步研究对于验证至关重要。