Suppr超能文献

在连续骨重塑框架内的骨折愈合

Bone fracture healing within a continuum bone remodelling framework.

作者信息

Schmidt Ina, Albert Jacob, Ritthaler Marina, Papastavrou Areti, Steinmann Paul

机构信息

Faculty of Mechanical Engineering, Nuremberg Tech, Nuremberg, Germany.

Institute of Applied Mechanics, University of Erlangen-Nuremberg, Erlangen, Germany.

出版信息

Comput Methods Biomech Biomed Engin. 2022 Jul;25(9):1040-1050. doi: 10.1080/10255842.2021.1998465. Epub 2021 Nov 3.

Abstract

Bone fracture healing is a complex process which is still under research. Computer-aided patient-specific prediction of bone development, fracture risk, prevention and treatment approaches promises a significant milestone in clinical practice. With this long-term goal in mind, a novel model is presented and examined in this work in the context of continuum bone remodelling. Therein, a clear distinction is made between external mechanical stimulation and the biological healing process of an injured bone tissue. The model is implemented within a finite element framework and investigated for the example of a fractured proximal femur head. The results show promising perspectives for further application. Besides, the model offers the possibility of easily integrating other factors like age-dependency and the availability of nutrition. For the future, further studies with large clinical datasets are essential for validation.

摘要

骨折愈合是一个仍在研究中的复杂过程。计算机辅助的针对特定患者的骨发育、骨折风险、预防和治疗方法的预测有望成为临床实践中的一个重要里程碑。出于这一长期目标,本文在连续骨重塑的背景下提出并检验了一种新模型。其中,明确区分了外部机械刺激和受伤骨组织的生物愈合过程。该模型在有限元框架内实现,并以近端股骨头骨折为例进行研究。结果显示了进一步应用的良好前景。此外,该模型还提供了轻松整合其他因素(如年龄依赖性和营养可用性)的可能性。未来,使用大型临床数据集进行进一步研究对于验证至关重要。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验