Williams Kylie E, Harrer Julia Andraca, LaBelle Steven A, Leguineche Kelly, Kaiser Jarred, Karipott Salil, Lin Angela, Vongphachanh Alyssa, Fulton Travis, Walker Rosenthal J, Muhib Farhan, Ong Keat Ghee, Weiss Jeffrey A, Willett Nick J, Guldberg Robert E
Phil and Penny Knight Campus for Accelerating Scientific Impact Department of Bioengineering, University of Oregon, Eugene, OR, 97403, USA.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
NPJ Regen Med. 2024 Dec 12;9(1):38. doi: 10.1038/s41536-024-00377-9.
Many studies have explored different loading and rehabilitation strategies, yet rehabilitation intensity and its impact on the local strain environment and bone healing have largely not been investigated. This study combined implantable strain sensors and subject-specific finite element models in a 2 mm rodent segmental bone defect model. After injury animals were underwent high or low intensity rehabilitation. High intensity rehabilitation increased local strains within the regenerative niche by an average of 44% compared to the low intensity rehabilitation. Finite element modeling demonstrated that resistance rehabilitation significantly increased compressive strain by a factor of 2.0 at week 2 and 4.45 after 4 weeks of rehabilitation. Animals that underwent resistance running had the greatest bone volume and improved functional recovery with regenerated femurs that matched intact failure torque and torsional stiffness values. These results demonstrate the potential for early resistance rehabilitation to improve bone healing.
许多研究探索了不同的负荷和康复策略，但康复强度及其对局部应变环境和骨愈合的影响在很大程度上尚未得到研究。本研究在一个2毫米的啮齿动物节段性骨缺损模型中，将可植入应变传感器与个体特异性有限元模型相结合。受伤后，动物接受高强度或低强度康复治疗。与低强度康复相比，高强度康复使再生微环境内的局部应变平均增加了44%。有限元建模表明，阻力康复在康复2周时使压缩应变显著增加了2.0倍，4周后增加了4.45倍。进行阻力跑步的动物骨体积最大，再生股骨的功能恢复得到改善，其破坏扭矩和扭转刚度值与完整股骨相当。这些结果表明早期阻力康复改善骨愈合的潜力。
