旧中出新：老龄骨骨折愈合的相关因素
[New from old : relevant factors for fracture healing in aging bone].
作者信息
Beckmann R, Tohidnezhad M, Lichte P, Wruck C J, Jahr H, Pape H C, Pufe T
机构信息
Institut für Anatomie und Zellbiologie, Universitätsklinikum der RWTH Aachen, Wendlingweg 2, 52074, Aachen, Deutschland,
出版信息
Orthopade. 2014 Apr;43(4):298-305. doi: 10.1007/s00132-013-2160-7.
BACKGROUND
Fracture healing is a complex biological process with specific temporal expression patterns. During this process new bone tissue is formed, which is similar to the original bone in quality and structure. This occurs in four phases: inflammation, formation of a soft tissue callus, formation of a bony callus and remodelling of the bony callus. This needs the precise orchestration of each cell type involved.
OBJECTIVES
This article presents details of the fracture healing phases and the relevant factors. During the aging process there is an increase of reactive oxygen species and a change in expression pattern of growth factors that have a negative effect on the fracture healing process.
METHODS
A selective review of the literature was carried out in PubMed concerning the influence of aging on fracture healing.
CONCLUSION
The healing process is regulated by systemic and local factors. An understanding of these processes and the changes during aging is necessary in order to improve the knowledge of delayed or lack of fracture healing during aging to decide when an intervention is needed.
背景
骨折愈合是一个具有特定时间表达模式的复杂生物学过程。在此过程中，会形成新的骨组织，其质量和结构与原始骨相似。这一过程分为四个阶段：炎症期、软组织骨痂形成期、骨性骨痂形成期和骨性骨痂重塑期。这需要所涉及的每种细胞类型精确协调配合。
目的
本文详述了骨折愈合阶段及相关因素。在衰老过程中，活性氧物质增加，生长因子表达模式改变，这些对骨折愈合过程产生负面影响。
方法
在PubMed上对有关衰老对骨折愈合影响的文献进行了选择性综述。
结论
愈合过程受全身和局部因素调节。了解这些过程以及衰老过程中的变化，对于增进对衰老过程中骨折愈合延迟或不愈合的认识、决定何时需要干预是必要的。
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