Department of Medical Parasitology, Faculty of Medicine, Misr University for Science and Technology, 6 October city, Egypt.
Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Rev Bras Parasitol Vet. 2021 Nov 1;30(4):e012021. doi: 10.1590/S1984-29612021084. eCollection 2021.
Trichinellosis is a zoonosis results from eating raw or semi-cooked meat of infected animals. Medicinal plants have been used lately as alternatives and/or combined therapies to resolve some drawbacks of the current regimens. This work analyzed the effect of albendazole monotherapy on Trichinella spiralis experimental infection (group A), in comparison to P. granatum and amygdalin extracts +cobalamin (group B), plus its combination with albendazole (group C). The study revealed that the extracts alone or combined with albendazole had an inferior effect to albendazole monotherapy regarding number of adult worms (40.83 ±3.82, 18.67 ±1.86 and 16.83 ±2.32, respectively). However, their effect was more obvious in muscle phase combined with albendazole, achieving the lower number of larvae/mL tissue homogenate (22.33 ±3.27 in comparison to 39.67 ±2.58 achieved by albendazole monotherapy). The extracts exerted a significant immunomodulatory effect by reducing the local CD4+ expression in the intestine as well as in muscle phase (1.15 ±0.25 and 3.80 ±0.65 in comparison to 4.97 ±0.37 and 12.20 ±0.87 with albendazole monotherapy, respectively). So, these extracts improved the therapeutic efficacy of albendazole, specifically in muscle phase and counteracted the inflammatory reaction caused by albendazole monotherapy, thus extensively alleviating the resulting myositis.
旋毛虫病是一种食源性疾病，由食用感染动物的生肉或半生肉引起。最近，药用植物已被用作替代药物和/或联合疗法，以解决当前方案的一些缺点。本工作分析了阿苯达唑单药治疗对旋毛虫实验感染的影响（A 组），并与石榴和苦杏仁提取物+钴胺素（B 组）进行比较，以及其与阿苯达唑的联合治疗（C 组）。研究表明，与阿苯达唑单药治疗相比，单独使用提取物或与阿苯达唑联合使用对成虫数量的影响较小（分别为 40.83 ±3.82、18.67 ±1.86 和 16.83 ±2.32）。然而，它们在与阿苯达唑联合使用时在肌肉阶段的效果更为明显，达到组织匀浆中幼虫/毫升的较低数量（与阿苯达唑单药治疗相比为 22.33 ±3.27）。提取物通过降低肠道和肌肉阶段的局部 CD4+表达来发挥显著的免疫调节作用（与阿苯达唑单药治疗相比，分别为 1.15 ±0.25 和 3.80 ±0.65）。因此，这些提取物提高了阿苯达唑的治疗效果，特别是在肌肉阶段，并对抗了阿苯达唑单药治疗引起的炎症反应，从而广泛缓解了由此引起的肌炎。
