Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2021 Oct 29;54(12):e11570. doi: 10.1590/1414-431X2021e11570. eCollection 2021.
Leishmaniasis is a serious and endemic infectious disease that has been reported in more than 90 countries and territories. The classical treatment presents a series of problems ranging from difficulty in administration, development of resistance, and a series of side effects. Photodynamic therapy (PDT) has already shown great potential for use as a treatment for leishmaniasis that is effective and non-invasive, with very minor side effects. PDT can also be inexpensive and easy to administer. In this review, we will report the most recent developments in the field, starting with the chemical diversity of photosensitizers, highlighting important mechanistic aspects, and noting information that may assist in designing and developing new and promising photosensitizer molecules.
利什曼病是一种严重的地方性传染病，已在 90 多个国家和地区报告。经典的治疗方法存在一系列问题，包括给药困难、耐药性的产生以及一系列副作用。光动力疗法 (PDT) 已显示出作为一种有效且非侵入性的利什曼病治疗方法的巨大潜力，副作用极小。PDT 还可以廉价且易于管理。在这篇综述中，我们将报告该领域的最新进展，首先是光敏剂的化学多样性，突出重要的机制方面，并指出可能有助于设计和开发新的有前途的光敏剂分子的信息。
