College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.
Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chem Commun (Camb). 2019 Dec 28;55(100):15057-15060. doi: 10.1039/c9cc08294h. Epub 2019 Nov 28.
We report a novel nanophotosensitizer via one-step covalent assembly of dopamine and genipin. This is the first report unveiling the photodynamic effect of dopamine-based materials. These nanophotosensitizers can also act as pH-responsive drug nanocarriers via a catechol-boronate linkage, thus achieving combined PDT and chemotherapy for highly efficient cancer treatment.
我们通过多巴胺和京尼平的一步共价组装报告了一种新型的纳米光敏剂。这是首次揭示基于多巴胺的材料的光动力效应的报道。这些纳米光敏剂还可以通过儿茶酚硼酸酯键作为 pH 响应性药物纳米载体，从而实现 PDT 和化疗的联合，以实现高效的癌症治疗。
