Thamm Roma, Buttmann-Schweiger Nina, Fiebig Julia, Poethko-Müller Christina, Prütz Franziska, Sarganas Giselle, Neuhauser Hannelore
Abteilung Epidemiologie und Gesundheitsmonitoring, Robert Koch-Institut, General-Pape-Str. 62-66, 12101, Berlin, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2021 Dec;64(12):1483-1491. doi: 10.1007/s00103-021-03448-0. Epub 2021 Nov 3.
SARS-CoV‑2 serologic studies complement and expand findings from confirmed COVID-19 cases through identification of undetected cases.
This article summarizes previous results on SARS-CoV‑2 prevalence from seroepidemiological studies in Germany focusing on children and adolescents and complements the already existing overview on seroprevalence in adults from general population samples and especially blood donors in Germany.
The results are based on an ongoing systematic search in study registries, in literature databases, of preprint publications, and of media reports of seroepidemiological studies in Germany and their results.
As of 17 September 2021, we are aware of 16 German seroepidemiological studies focusing on children and adolescents. Results are available for nine of these studies. For almost all settings studied, SARS-CoV‑2 seroprevalence was well below 1% for preschool and elementary school children in the first COVID-19 wave and below 2% for adolescents. As the pandemic progressed, higher seroprevalences of up to 8% were found in elementary school children.
Results of SARS-CoV‑2 antibody studies in children and adolescents in Germany are scarce so far and are based on non-representative samples at local or regional level. In future studies, it is necessary on the one hand to estimate which proportion of children and adolescents has already either had an infection or has been vaccinated. On the other hand, it is important to investigate physical and mental health impairments that occur after an infection.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）血清学研究通过识别未被检测到的病例，补充并扩展了确诊的2019冠状病毒病（COVID-19）病例的研究结果。
本文总结了德国针对儿童和青少年的血清流行病学研究中关于SARS-CoV-2流行率的先前结果，并补充了德国普通人群样本尤其是献血者中成人血清流行率的现有综述。
研究结果基于对德国血清流行病学研究及其结果在研究注册库、文献数据库、预印本出版物和媒体报道中的持续系统检索。
截至2021年9月17日，我们知晓有16项德国血清流行病学研究聚焦于儿童和青少年。其中9项研究有结果。在几乎所有研究的环境中，在第一波COVID-19疫情期间，学龄前儿童和小学生的SARS-CoV-2血清流行率远低于1%，青少年低于2%。随着疫情的发展，小学生中发现了高达8%的更高血清流行率。
目前德国关于儿童和青少年的SARS-CoV-2抗体研究结果稀缺，且基于当地或区域层面的非代表性样本。在未来的研究中，一方面有必要估计儿童和青少年中已经感染或接种疫苗的比例。另一方面，调查感染后出现的身心健康损害很重要。
