Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Lehigh Valley Health Network, Allentown, PA, USA.
Int J Colorectal Dis. 2022 Feb;37(2):313-321. doi: 10.1007/s00384-021-04056-9. Epub 2021 Nov 3.
The burden of psychiatric disorders is on a rise in inflammatory bowel disease (IBD) patients which has shown to effect medication compliance and overall clinical outcomes. We studied the prevalence of depression and anxiety in IBD patients when compared to individuals with other chronic medical conditions.
This is a retrospective cohort study using the United States national inpatient sample of 2016 to 2018. We identified patient encounters with a diagnosis of IBD. Our primary outcome was prevalence of depression and anxiety in IBD patients when compared to general adult population with other chronic medical conditions. We further studied these outcomes in subgroups of patients with ulcerative colitis and Crohn's disease.
A total of 963,619 patient encounters were identified with the diagnosis of IBD between 2016 and 2018, of them 162,850 (16.9%) had depression and 201,685 (20.9%) had anxiety. The prevalence of depression and anxiety was significantly higher in IBD patients in comparison to general population, (16.9% vs 12.3%) and (20.9% vs 15%) respectively (p < 0.001). Association of depression and anxiety was also higher in IBD patients when compared to patients with other chronic conditions like diabetes, metastatic cancer, and coronary artery disease. Crohn's disease and ulcerative colitis were independently associated with increased odds of depression and anxiety and these results were statistically significant (p < 0.001).
IBD is associated with increased prevalence of depression and anxiety when compared to general population. Association of these psychiatric illnesses with IBD is significantly higher when compared to other chronic medical conditions.
精神疾病在炎症性肠病（IBD）患者中的负担正在增加，这已表明会影响药物依从性和整体临床结果。我们研究了 IBD 患者与患有其他慢性疾病的个体相比抑郁和焦虑的患病率。
这是一项使用 2016 年至 2018 年美国国家住院患者样本的回顾性队列研究。我们确定了患有 IBD 的患者就诊情况。我们的主要结局是将 IBD 患者的抑郁和焦虑患病率与患有其他慢性疾病的普通成年人群进行比较。我们进一步研究了溃疡性结肠炎和克罗恩病患者亚组中的这些结果。
在 2016 年至 2018 年间，共确定了 963619 例患有 IBD 的患者就诊，其中 162850 例（16.9%）患有抑郁症，201685 例（20.9%）患有焦虑症。与普通人群相比，IBD 患者中抑郁和焦虑的患病率明显更高（16.9%比 12.3%）和（20.9%比 15%）（p<0.001）。与患有其他慢性疾病（如糖尿病、转移性癌症和冠状动脉疾病）的患者相比，IBD 患者中抑郁和焦虑的关联也更高。克罗恩病和溃疡性结肠炎与抑郁和焦虑的发生几率增加独立相关，且这些结果具有统计学意义（p<0.001）。
与普通人群相比，IBD 患者抑郁和焦虑的患病率更高。与其他慢性疾病相比，这些精神疾病与 IBD 的关联更高。
