Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
Dermatol Ther. 2022 Jan;35(1):e15186. doi: 10.1111/dth.15186. Epub 2021 Nov 17.
Seborrhea and the associated oily skin are undoubtedly the problem of women and men around the world. The pathogenesis of acne vulgaris involves excessive activity of sebaceous glands, as well as disturbances in the composition of sebum. The aim of the study was to assess the severity of seborrhea in a group of acne vulgaris patients and to determine the effect of a 20% azelaic acid solution on the activity of sebaceous glands. Twenty seven women, aged 19-25 years, underwent a series of six treatments with the application of a 20% solution of azelaic acid to the face. The mean values of sebum level showed a decreasing tendency. On the forehead, the results were as follows-195.5 before the treatment and 162.7 2 weeks after the last treatment. Measurements of the right cheek decreased from 175.3 to 141.3 The measurements taken 3 months after the study were 151.3 on the forehead and 138.9 on the cheek. Similarly, the values determining the total number of acne lesions and the severity of the disease according to the IGA scale also changed significantly. Chemical peel with 20% azelaic acid shows long-term sebostatic action, which inhibits the formation of new acne lesions.
皮脂溢和相关的油性皮肤无疑是全世界女性和男性的问题。寻常痤疮的发病机制涉及皮脂腺过度活跃，以及皮脂组成的紊乱。本研究的目的是评估一组寻常痤疮患者皮脂溢的严重程度，并确定 20%壬二酸溶液对皮脂腺活性的影响。27 名年龄在 19-25 岁的女性接受了一系列六次治疗，在面部涂抹 20%壬二酸溶液。皮脂水平的平均值呈下降趋势。在前额，结果为-治疗前 195.5，最后一次治疗后 2 周 162.7。右脸颊的测量值从 175.3 降至 141.3。研究 3 个月后，前额和脸颊的测量值分别为 151.3 和 138.9。同样，根据 IGA 量表确定的总痤疮病变数量和疾病严重程度的值也发生了显著变化。20%壬二酸化学换肤具有长期的抑制皮脂作用，可抑制新痤疮病变的形成。
