Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Clin Exp Dermatol. 2022 Mar;47(3):591-592. doi: 10.1111/ced.15002. Epub 2021 Nov 25.
With the expansion of the COVID-19 vaccination drive, an increasing number of adverse effects are surfacing. A 74-year-old woman presented with multiple erythematous and itchy patches on several sites. She had no relevant medical history, apart from the first AZD1222 vaccination 1 month previously. Microscopically, epidermal changes, including mild spongiosis and parakeratosis, were observed. Tight perivascular lymphocytic infiltration (coat-sleeve pattern) was also observed in the dermis. The final diagnosis was erythema annulare centrifugum (EAC) induced by SARS-CoV-2 vaccination. Based on this report, dermatologists should be aware of the possibility of EAC from the AZD1222 vaccination.
随着 COVID-19 疫苗接种工作的扩大，越来越多的不良反应浮出水面。一名 74 岁女性出现多处红斑和瘙痒斑块。除了 1 个月前接种第一剂 AZD1222 疫苗外，她没有相关的医疗病史。镜下观察到表皮变化，包括轻度海绵形成和角化不良。真皮中还观察到围绕血管的淋巴细胞浸润（套袖样模式）。最终诊断为 SARS-CoV-2 疫苗接种引起的环状离心红斑（EAC）。基于此报告，皮肤科医生应该意识到 AZD1222 疫苗接种后可能会出现 EAC。
