Department of Speech, Language & Hearing Sciences, Boston University, MA.
Department of Biomedical Engineering, Boston University, MA.
J Speech Lang Hear Res. 2021 Dec 13;64(12):4682-4694. doi: 10.1044/2021_JSLHR-21-00153. Epub 2021 Nov 3.
Unexpected and sustained manipulations of auditory feedback during speech production result in "reflexive" and "adaptive" responses, which can shed light on feedback and feedforward auditory-motor control processes, respectively. Persons with Parkinson's disease (PwPD) have shown aberrant reflexive and adaptive responses, but responses appear to differ for control of vocal and articulatory features. However, these responses have not been examined for both voice and articulation in the same speakers and with respect to auditory acuity and functional speech outcomes (speech intelligibility and naturalness).
Here, 28 PwPD on their typical dopaminergic medication schedule and 28 age-, sex-, and hearing-matched controls completed tasks yielding reflexive and adaptive responses as well as auditory acuity for both vocal and articulatory features.
No group differences were found for any measures of auditory-motor control, conflicting with prior findings in PwPD while off medication. Auditory-motor measures were also compared with listener ratings of speech function: first formant frequency acuity was related to speech intelligibility, whereas adaptive responses to vocal fundamental frequency manipulations were related to speech naturalness.
These results support that auditory-motor processes for both voice and articulatory features are intact for PwPD receiving medication. This work is also the first to suggest associations between measures of auditory-motor control and speech intelligibility and naturalness.
在言语产生过程中，对听觉反馈进行意想不到且持续的操作会导致“反射性”和“适应性”反应，这分别可以揭示反馈和前馈听觉运动控制过程。帕金森病患者（PwPD）表现出异常的反射性和适应性反应，但对于声音和发音特征的控制，这些反应似乎有所不同。然而，在同一说话者中，尚未针对声音和发音同时检查这些反应，也没有针对听觉敏锐度和功能言语结果（言语可懂度和自然度）进行检查。
在这里，28 名处于典型多巴胺能药物治疗方案下的 PwPD 和 28 名年龄、性别和听力匹配的对照者完成了任务，这些任务产生了反射性和适应性反应，以及声音和发音特征的听觉敏锐度。
在任何听觉运动控制测量中都没有发现组间差异，这与 PwPD 在停药时的先前发现相矛盾。听觉运动测量还与听众对言语功能的评分进行了比较：第一共振峰频率敏锐度与言语可懂度相关，而对声音基频操纵的适应性反应与言语自然度相关。
这些结果支持接受药物治疗的 PwPD 的声音和发音特征的听觉运动过程完好无损。这项工作也是首次表明听觉运动控制措施与言语可懂度和自然度之间存在关联。
