Alison R H, Morgan K T, Haseman J K, Boorman G A
J Natl Cancer Inst. 1987 Jun;78(6):1229-43.
For the updating of the National Toxicology Program (NTP) classification system for rat and mouse ovarian tumors, all the primary ovarian tumors from the archives of the National Cancer Institute and NTP Carcinogenesis Testing Programs were reviewed. The relative frequency and principal diagnostic features of 204 ovarian tumors from 39,851 female F344 rats and of 587 ovarian tumors from 41,102 female (C57BL/6 X C3H)F1 (B6C3F1) mice were described. The most frequently observed neoplasms in F344 rats were malignant granulosa cell tumors (29% of primary rat ovarian neoplasms observed), benign undifferentiated sex cord-stromal tumors (26%), benign granulosa cell tumors (16%), and benign Sertoli cell tumors (7%). The most frequent neoplasms in B6C3F1 mice were cystadenomas (24%), tubulostromal adenomas (24%), benign granulosa cell tumors (21%), and benign teratomas (8%). Ovarian neoplasms were not significantly related to treatment in rats. Tubulostromal adenomas, benign and malignant granulosa cell tumors, and benign teratomas were significantly more frequent in treated mice than in controls.
为更新国家毒理学计划（NTP）对大鼠和小鼠卵巢肿瘤的分类系统，对美国国立癌症研究所档案以及NTP致癌性测试计划中的所有原发性卵巢肿瘤进行了审查。描述了来自39,851只雌性F344大鼠的204个卵巢肿瘤以及来自41,102只雌性（C57BL/6×C3H）F1（B6C3F1）小鼠的587个卵巢肿瘤的相对频率和主要诊断特征。在F344大鼠中最常观察到的肿瘤是恶性颗粒细胞瘤（占观察到的原发性大鼠卵巢肿瘤的29%）、良性未分化性索间质肿瘤（26%）、良性颗粒细胞瘤（16%）和良性支持细胞瘤（7%）。在B6C3F1小鼠中最常见的肿瘤是囊腺瘤（24%）、管状间质腺瘤（24%）、良性颗粒细胞瘤（21%）和良性畸胎瘤（8%）。卵巢肿瘤与大鼠的治疗无显著相关性。在接受治疗的小鼠中，管状间质腺瘤、良性和恶性颗粒细胞瘤以及良性畸胎瘤的发生频率显著高于对照组。
