Maekawa A, Onodera H, Matsushima Y, Nagaoka T, Todate A, Kanno J, Shibutani M, Ogasawara H, Yoshida J, Hayashi Y
Division of Pathology, National Institute of Hygienic Sciences, Tokyo.
Jpn J Cancer Res. 1990 Nov;81(11):1077-80. doi: 10.1111/j.1349-7006.1990.tb02514.x.
Ovarian tumors were induced at very high incidence in the offspring of F344 rats receiving 3 subcutaneous injections of 10 mg/kg of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th and 20 days of gestation. Histologically, all ovarian tumors were of the granulosa cell tumor and/or luteoma type. Many of them consisted of large, polygonal cells with abundant eosinophilic or vacuolated cytoplasm, arranged in sheets or in a pseudo-palisaded pattern separated by thin fibrovascular stroma, and they exhibited typical luteoma morphological character. The high yields, and the similarities in morphology as well as putative hormonal influence suggest that this experimental system may serve as a good animal model for granulosa cell tumor and/or luteoma development in women.
在妊娠第14、18和20天给F344大鼠皮下注射3次10 mg/kg的N-亚硝基双（2-氧代丙基）胺，其后代中卵巢肿瘤的诱发率非常高。组织学上，所有卵巢肿瘤均为颗粒细胞瘤和/或黄体瘤类型。其中许多由大的多边形细胞组成，细胞质丰富，呈嗜酸性或空泡状，排列成片或呈假栅栏状，由薄的纤维血管间质分隔，并且表现出典型的黄体瘤形态特征。高发生率、形态学相似性以及假定的激素影响表明，该实验系统可作为研究女性颗粒细胞瘤和/或黄体瘤发生的良好动物模型。
