F344大鼠和B6C3F1小鼠的卵巢肿瘤

Ovarian neoplasms in F344 rats and B6C3F1 mice.

作者信息

Alison R H, Morgan K T

机构信息

National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

出版信息

Environ Health Perspect. 1987 Aug;73:91-106. doi: 10.1289/ehp.877391.

The National Toxicology Program (NTP) classification system for rat and mouse ovarian tumors is presented. The classification system is based on previous classification systems and on a review of all the primary ovarian tumors from the archives of the National Cancer Institute (NCI) and NTP Carcinogenesis Testing Programs. The relative frequency and principal diagnostic features of 204 ovarian tumors from 39,851 female F344 rats and 587 ovarian tumors from 41,102 female B6C3F1 mice are described. The most frequently observed neoplasms in F344 rats were malignant granulosa cell tumors (29% of primary rat ovarian neoplasms observed), benign undifferentiated sex cord-stromal tumors (26%), benign granulosa cell tumors (16%), and benign Sertoli cell tumors (7%). The most frequent neoplasms in B6C3F1 mice were cystadenomas (24%), tubulostromal adenomas (24%), benign granulosa cell tumors (21%), and benign teratomas (8%).

本文介绍了美国国家毒理学计划（NTP）对大鼠和小鼠卵巢肿瘤的分类系统。该分类系统基于以往的分类系统，并对美国国立癌症研究所（NCI）和NTP致癌性测试项目档案中的所有原发性卵巢肿瘤进行了回顾。描述了来自39,851只雌性F344大鼠的204个卵巢肿瘤以及来自41,102只雌性B6C3F1小鼠的587个卵巢肿瘤的相对频率和主要诊断特征。在F344大鼠中最常观察到的肿瘤是恶性颗粒细胞瘤（占观察到的原发性大鼠卵巢肿瘤的29%）、良性未分化性索间质肿瘤（26%）、良性颗粒细胞瘤（16%）和良性支持细胞瘤（7%）。在B6C3F1小鼠中最常见的肿瘤是囊腺瘤（24%）、小管间质腺瘤（24%）、良性颗粒细胞瘤（21%）和良性畸胎瘤（8%）。