Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sci Rep. 2021 Nov 3;11(1):21548. doi: 10.1038/s41598-021-01100-0.
ROI analysis is frequently used for obtaining acid content on rapid-kV-switching dual energy CT (DECT), providing inadequate accuracy. A new parameter derived from post-processing procedure, maximum lower limit with stain visible (MLLSV), was used by us to diagnose gout. 30 gout patients and 20 healthy volunteers were analyzed by using MLLSV. MLLSV was defined as the maximum lower limit of display window allowing only one stained site visible. Radiologists were asked to continuously increase the lower limit of display window of uric acid to decrease number of stained sites until the last stained site disappeared. MLLSV obtained by this way was compared between gout patients and volunteers. Receiver operating characteristic (ROC) curve was used to determine the performance. MLLSV of gout patients was significantly higher than that of volunteers (1373.3 ± 23.0 mg/cm vs. 1315.4 ± 20.7 mg/cm, p = 0.000). The area under ROC curve of MLLSV was 0.993 in identifying gout. When using the optimal cutoff of 1342 mg/cm, the sensitivity and specificity of MLLSV in identification of gout were 96.7% and 95% respectively. MLLSV derived from post-processing procedure of DECT is useful in discriminating gout patients from healthy people.
ROI 分析常用于快速-kV 切换双能 CT（DECT）获取尿酸含量，但准确性不足。我们使用一种新的参数，即最大可见染色下限（MLLSV），用于诊断痛风。对 30 例痛风患者和 20 名健康志愿者进行 MLLSV 分析。MLLSV 定义为仅允许一个染色部位可见的显示窗的最大下限。要求放射科医生连续增加尿酸显示窗的下限，以减少染色部位的数量，直到最后一个染色部位消失。比较痛风患者和志愿者之间的 MLLSV。使用受试者工作特征（ROC）曲线确定性能。痛风患者的 MLLSV 明显高于志愿者（1373.3 ± 23.0 mg/cm 比 1315.4 ± 20.7 mg/cm，p = 0.000）。MLLSV 鉴别痛风的 ROC 曲线下面积为 0.993。当使用 1342 mg/cm 的最佳截止值时，MLLSV 鉴别痛风的敏感性和特异性分别为 96.7%和 95%。DECT 后处理程序得出的 MLLSV 有助于区分痛风患者和健康人。
