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冻融胚胎移植中是否预处理 GnRH 激动剂的子宫内膜准备：两个中心的随机对照试验。

Endometrial Preparation for Frozen-Thawed Embryo Transfer With or Without Pretreatment With GnRH Agonist: A Randomized Controlled Trial at Two Centers.

机构信息

Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Reproductive Medicine center, Jiangmen Central Hospital, Affiliated Hospital of Sun Yat-Sen University, Jiangmen, China.

出版信息

Front Endocrinol (Lausanne). 2021 Oct 18;12:722253. doi: 10.3389/fendo.2021.722253. eCollection 2021.

DOI:10.3389/fendo.2021.722253
PMID:34733238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8559785/
Abstract

OBJECTIVE

This prospective randomized controlled trial compared the reproductive outcomes of frozen embryo transfer (FET) with hormone replacement treatment (HRT) with or without gonadotropin-releasing hormone agonist (GnRHa) pretreatment.

METHODS

A total of 133 patients scheduled for HRT-FET mainly because of tubal and/or male factors who received two high-quality cleavage-stage embryos were enrolled at two participating centers. The GnRHa group ( = 65) received GnRHa pretreatment, while the control group ( = 68) did not. Analysis was based on the intention-to-treat (ITT) principle.

RESULTS

Among the 133 participants, 130 (97.7%) underwent embryo transfer and 127 (95.5%) completed the protocol. The clinical pregnancy rate according to ITT did not differ between the GnRHa and control groups [39/65 (60.0%) . 41/68 (60.3%), = 0.887]. The implantation rate (47.6% . 45.3%, = 0.713), early pregnancy loss rate (5.1% . 19.5%, = 0.09), and live birth rate (49.2% . 50.0%, = 0.920) were also comparable between groups.

CONCLUSION

Pretreatment with GnRHa does not improve the reproductive outcomes for women receiving HRT-FET.

CLINICAL TRIAL REGISTRATION

The study was registered with the Chinese Clinical Trial Registry (ChiCTR-IOR-17014170; http://www.chictr.org.cn).

摘要

目的

本前瞻性随机对照试验比较了激素替代治疗（HRT）联合或不联合促性腺激素释放激素激动剂（GnRHa）预处理的冻融胚胎移植（FET）的生殖结局。

方法

本研究纳入了在两个参与中心就诊、因输卵管和/或男性因素拟行 HRT-FET 且接受了两枚高质量卵裂期胚胎的 133 名患者。GnRHa 组（n=65）接受了 GnRHa 预处理，而对照组（n=68）未接受。分析基于意向治疗（ITT）原则。

结果

在 133 名参与者中，有 130 名（97.7%）进行了胚胎移植，127 名（95.5%）完成了方案。根据 ITT，GnRHa 组和对照组的临床妊娠率无差异[39/65（60.0%）. 41/68（60.3%），=0.887]。两组的种植率（47.6%. 45.3%，=0.713）、早期妊娠丢失率（5.1%. 19.5%，=0.09）和活产率（49.2%. 50.0%，=0.920）也相似。

结论

在接受 HRT-FET 的女性中，预处理加用 GnRHa 并不能改善其生殖结局。

临床试验注册

本研究在中国临床试验注册中心注册（ChiCTR-IOR-17014170；http://www.chictr.org.cn）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd7/8559785/a4fa7e4197d3/fendo-12-722253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd7/8559785/a4fa7e4197d3/fendo-12-722253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dd7/8559785/a4fa7e4197d3/fendo-12-722253-g001.jpg

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