Kpossou Aboudou Raïmi, Kouwakanou Benoît, Sokpon Comlan N Déhougbèa Martin, Alassane Khadidjatou Saké, Bankolé Marc Moboladji, Ahouada Carin, Vignon Rodolph Koffi, Zoundjiekpon Vincent, Sourokou Fadel, Séhonou Jean, Kodjoh Nicolas
Clinique Universitaire d'Hépato-gastroentérologie, Centre National Hospitalier et Universitaire Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Bénin.
Service d´Hépato-gastroentérologie, CHU Mohammed VI de Marrakech, Marrakech, Maroc.
Pan Afr Med J. 2021 Sep 10;40:30. doi: 10.11604/pamj.2021.40.30.28775. eCollection 2021.
hepatitis C is a public health problem worldwide, in particular in sub-Saharan Africa. The purpose of this study is to determine the seroprevalence of hepatitis C virus antibodies and associated factors during a voluntary general population screening program in Benin.
we conducted a descriptive and analytical cross-sectional study in 4 big cities of 4 different departments in Benin in July 2016. All volunteers of all ages, residing in these targeted cities, who gave their informed consent were included in the study. ImuMed HCV Rapid Diagnostic Test (Healgen Scientific LLC, USA) was used. Logistic regression analysis was also used to identify factors associated with hepatitis C virus infection.
a total of 2809 volunteers with an average age of 25.9 ± 16.5 years (ranging from 0 to 86 years) were included in the study; 53.9% (1514/2809) of them were men and 46.1% (1295/2809) were women. More than half of the study population consisted of single (59.1%; 1612/2726); 41.3% (1074/2809) were pupils or students. VHC Seroprevalence was 1.5% (42/2809). In multivariate analysis, the variables significantly associated with anti-HCV carriage were: be 60 years old and older (aOR: 46.9, 95% CI 10.2-216.0; p<0.0001) and a history of alcoholism (aOR: 6.3; 95% CI 95% 3.3-12.1; p < 0.0001).
in the general population, the seroprevalence of anti-HCV antibodies was 1.5%. HCV infection mainly occurred in people aged 60 years and older and in those with a history of alcoholism.
丙型肝炎是一个全球性的公共卫生问题，在撒哈拉以南非洲地区尤为突出。本研究的目的是确定在贝宁的一项自愿性普通人群筛查项目中丙型肝炎病毒抗体的血清流行率及相关因素。
2016年7月，我们在贝宁4个不同省份的4个大城市开展了一项描述性和分析性横断面研究。所有居住在这些目标城市、年龄各异且签署知情同意书的志愿者均纳入研究。采用美国Healgen Scientific LLC公司的ImuMed HCV快速诊断检测。还采用逻辑回归分析来确定与丙型肝炎病毒感染相关的因素。
共有2809名志愿者纳入研究，平均年龄为25.9±16.5岁（年龄范围为0至86岁）；其中53.9%（1514/2809）为男性，46.1%（1295/2809）为女性。研究人群中超过一半为单身（59.1%；1612/2726）；41.3%（1074/2809）为小学生或学生。丙型肝炎病毒血清流行率为1.5%（42/2809）。多因素分析显示，与抗-HCV携带显著相关的变量为：年龄60岁及以上（调整后比值比：46.9，95%置信区间10.2 - 216.0；p<0.0001）和酗酒史（调整后比值比：6.3；95%置信区间3.3 - 12.1；p < 0.0001）。
在普通人群中，抗-HCV抗体的血清流行率为1.5%。丙型肝炎病毒感染主要发生在60岁及以上人群和有酗酒史的人群中。
