Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, George Town, Malaysia.
Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, George Town, Malaysia.
Front Public Health. 2021 Oct 18;9:657199. doi: 10.3389/fpubh.2021.657199. eCollection 2021.
Urinary tract infections (UTIs) are the second most prevalent infection among the elderly population. Hence, the current study aimed to evaluate the prevalence of UTIs among older adults, medication regimen complexity, and the factors associated with the treatment outcomes of elderly patients infected with UTIs. A retrospective cross-sectional study was conducted at the Department of Urology, Hospital Pulau Pinang, Malaysia. The patients ≥65 years of age were included in the present study with a confirmed diagnosis of UTIs from 2014 to 2018 (5 years). A total of 460 patients met the inclusion criteria and were included in the present study. Cystitis (37.6%) was the most prevalent UTI among the study population followed by asymptomatic bacteriuria (ASB) (31.9%), pyelonephritis (13.9%), urosepsis (10.2%), and prostatitis (6.4%). Unasyn (ampicillin and sulbactam) was used to treat the UTIs followed by Bactrim (trimethoprim/sulfamethoxazole), and ciprofloxacin. The factors associated with the treatment outcomes of UTIs were gender (odd ratio [] = 1.628; = 0.018), polypharmacy ( = 0.647; = 0.033), and presence of other comorbidities ( = 2.004; = 0.002) among the study population. Cystitis is the most common UTI observed in older adults. Gender, the burden of polypharmacy, and the presence of comorbidities are the factors that directly affect the treatment outcomes of UTIs among the study population.
尿路感染(UTIs)是老年人中第二大常见感染。因此,本研究旨在评估老年人 UTI 的患病率、药物治疗方案的复杂性以及与老年尿路感染患者治疗结果相关的因素。这是一项在马来西亚槟城医院泌尿科进行的回顾性横断面研究。本研究纳入了 2014 年至 2018 年(5 年)年龄≥65 岁且确诊为 UTI 的患者。共有 460 名患者符合纳入标准,并纳入本研究。膀胱炎(37.6%)是研究人群中最常见的 UTI,其次是无症状菌尿(ASB)(31.9%)、肾盂肾炎(13.9%)、尿脓毒症(10.2%)和前列腺炎(6.4%)。治疗 UTI 最常用的药物是 Unasyn(氨苄西林和舒巴坦),其次是 Bactrim(复方磺胺甲噁唑)和环丙沙星。与 UTI 治疗结果相关的因素是性别(优势比[]=1.628;=0.018)、多药治疗(=0.647;=0.033)和其他合并症的存在(=2.004;=0.002)。膀胱炎是老年人中最常见的 UTI。性别、多药治疗的负担以及合并症的存在是直接影响研究人群 UTI 治疗结果的因素。