Ling Liying, Zhu Lei, Li Yibao, Liu Chunhua, Cheng Linxiu
Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, China.
Research Center for Environmental Engineering and Technology, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, China.
Front Bioeng Biotechnol. 2021 Oct 18;9:703582. doi: 10.3389/fbioe.2021.703582. eCollection 2021.
Stimulus-responsive hydrogels are significantly programmable materials that show potential applications in the field of biomedicine and the environment. Ultrasound as a stimulus can induce the formation of hydrogels, which exhibit the superior performance of different structures. In this study, we reported an ultrasound-induced supramolecular hydrogel based on aspartic acid derivative ,'-diaspartate-3,4,9,10-perylene tetracarboxylic acid imide, showing superior performance in drug release. The results show that the driving force of this ultrasonic induced hydrogel could be attributed to hydrogen bonding and π-π interaction. The rheological and cytotoxicity test illustrate excellent mechanical properties and biocompatibility of the hydrogel. The anti- cercariae (CC) drug release results show large drug loadings (500 mg/ml) and long-term release (15 days) of this hydrogel. This study demonstrates that this hydrogel may serve as a slow-release platform for anti-CC.
刺激响应性水凝胶是具有显著可编程性的材料，在生物医学和环境领域显示出潜在应用。超声作为一种刺激可诱导水凝胶形成，这些水凝胶展现出不同结构的卓越性能。在本研究中，我们报道了一种基于天冬氨酸衍生物、'-二天冬氨酸-3,4,9,10-苝四羧酸二酰亚胺的超声诱导超分子水凝胶，其在药物释放方面表现出卓越性能。结果表明，这种超声诱导水凝胶的驱动力可归因于氢键和π-π相互作用。流变学和细胞毒性测试表明该水凝胶具有优异的力学性能和生物相容性。抗尾蚴（CC）药物释放结果显示这种水凝胶具有高载药量（500毫克/毫升）和长期释放（15天）的特性。本研究表明这种水凝胶可作为抗CC的缓释平台。
