Ministry of Education Key Laboratory of Industrial Biotechnology, School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.
National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.
Molecules. 2022 Jul 2;27(13):4268. doi: 10.3390/molecules27134268.
, one of the 100 most destructive invasive species in the world, and it is an important intermediate host of . The molluscicides in current use are an effective method for controlling snails. However, most molluscicides have no slow-release effect and are toxic to nontarget organisms. Thus, these molluscicides cannot be used on a large scale to effectively act on snails. In this study, gelatin, a safe and nontoxic substance, was combined with sustained-release molluscicide and was found to reduce the toxicity of niclosamide to nontarget organisms. We assessed the effects of gelatin and molluscicide in controlling snails and eggs. The results demonstrated that the niclosamide retention time with 1.0% and 1.5% gelatin sustained-release agents reached 20 days. Additionally, the mortality rate of and their eggs increased as the concentration of the niclosamide sustained-release agents increased. The adult mortality rate of reached 50% after the snails were exposed to gelatin with 0.1 mg/L niclosamide for 48 h. The hatching rate of was only 28.5% of the normal group after the treatment was applied. The sustained-release molluscicide at this concentration was less toxic to zebrafish, which means that this molluscicide can increase the safety of niclosamide to control in aquatic environments. In this study, we explored the safety of using niclosamide sustained-release agents with gelatin against . The results suggest that gelatin is an ideal sustained-release agent that can provide a foundation for subsequent improvements in control of .
钉螺是世界上 100 种最具破坏力的入侵物种之一，是 的重要中间宿主。目前使用的杀螺剂是控制蜗牛的有效方法。然而，大多数杀螺剂没有缓释效果，对非目标生物有毒。因此，这些杀螺剂不能大规模使用，无法有效地作用于蜗牛。在这项研究中，明胶作为一种安全无毒的物质，与缓释杀螺剂结合使用，发现可以降低氯硝柳胺对非目标生物的毒性。我们评估了明胶和杀螺剂控制 蜗牛和卵的效果。结果表明，含有 1.0%和 1.5%明胶缓释剂的氯硝柳胺保留时间达到 20 天。此外，随着氯硝柳胺缓释剂浓度的增加， 和它们的卵的死亡率增加。蜗牛暴露在含有 0.1 毫克/升氯硝柳胺的明胶中 48 小时后， 的成虫死亡率达到 50%。处理后， 的孵化率仅为正常组的 28.5%。在这个浓度下，缓释杀螺剂对斑马鱼的毒性较小，这意味着这种杀螺剂可以提高氯硝柳胺在水生环境中控制 的安全性。在这项研究中，我们探讨了使用含有明胶的氯硝柳胺缓释剂对 的安全性。结果表明，明胶是一种理想的缓释剂，可以为后续改进 控制提供基础。
