Li Yibao, Zhu Lei, Fan Yulan, Li Yayun, Cheng Linxiu, Liu Wei, Li Xun, Fan Xiaolin
Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China.
Nanomaterials (Basel). 2016 Mar 9;6(3):46. doi: 10.3390/nano6030046.
A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π-π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment.
构建了一种基于核黄素、三聚氰胺和氨基酸衍生物的新型三组分超分子水凝胶，用于农药氯硝柳胺衍生物的控释。水凝胶的形成可能归因于通过氢键和π-π相互作用的自组装，这已通过扫描电子显微镜（SEM）和傅里叶变换红外（FT-IR）光谱进行了研究。流变学实验表明，水凝胶材料和载药水凝胶均表现出良好的机械强度和高稳定性。进一步的实验结果表明，载药水凝胶具有较大的载药量、较长的释放时间以及在水环境中相对较高的抗尾蚴效率。
