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接受雌激素治疗的女性接种牛津-阿斯利康 COVID-19 疫苗后发生血栓栓塞事件的可能风险。

Possible Risk of Thrombotic Events following Oxford-AstraZeneca COVID-19 Vaccination in Women Receiving Estrogen.

机构信息

Department of Physiology, Fasa University of Medical Sciences, Fasa, Iran.

出版信息

Biomed Res Int. 2021 Oct 25;2021:7702863. doi: 10.1155/2021/7702863. eCollection 2021.

DOI:10.1155/2021/7702863
PMID:34734086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8560237/
Abstract

People who receive the ChAdOx1 nCoV-19 vaccine, particularly perimenopausal women who are on birth control or postmenopausal women who take estrogen supplements, may experience thrombosis and thrombocytopenia. Estrogen and the ChAdOx1 nCoV-19 vaccine both have the potential to cause thrombus in different ways. Some postmenopausal women who are also taking estrogens may develop thrombosis and thrombocytopenia after receiving the ChAdOx1 nCoV-19 vaccine. Therefore, women are encouraged to stop taking drugs containing estrogen before receiving this vaccine. Furthermore, consuming fish oil can help reduce the risk of developing blood clots among women who are in the luteal phase and, thus, have high estrogen levels. In addition, ChAdOx1 nCoV-19's side effects in young women could be mitigated by administering it during the follicular phase.

摘要

接种 ChAdOx1 nCoV-19 疫苗的人,尤其是正在服用避孕药的围绝经期妇女或服用雌激素补充剂的绝经后妇女,可能会出现血栓和血小板减少症。雌激素和 ChAdOx1 nCoV-19 疫苗都有可能以不同的方式导致血栓。一些同时服用雌激素的绝经后妇女在接种 ChAdOx1 nCoV-19 疫苗后可能会出现血栓和血小板减少症。因此,建议女性在接种该疫苗前停止服用含有雌激素的药物。此外,服用鱼油可以帮助处于黄体期且雌激素水平较高的女性降低血栓形成的风险。此外,在卵泡期接种 ChAdOx1 nCoV-19 可以减轻年轻女性的副作用。

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