School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Core Facility Center, Capital Medical University, Beijing 100069, China.
Chem Commun (Camb). 2021 Nov 19;57(92):12293-12296. doi: 10.1039/d1cc05000a.
The hydroxyl radical (˙OH), generated from Fenton/Fenton-like reactions of iron(II) species in biology, can oxidatively damage biomolecules, inducing oxidative stress and diseases. However, this common understanding has been questioned recently after a carbonate radical was observed from the Fenton-like reaction of the iron(II)-carbonate complex. Herein, we report that the Fenton-like reaction of the iron(II)-histidine complex, one major iron(II) species in blood plasma, can occur at neutral pH to generate ˙OH, not iron(IV). Our findings and critical analyses on relevant studies clarify the above doubt, reveal a new pathway of causing oxidative stress by the iron(II) species, and have implications for Alzheimer's disease.
羟基自由基（˙OH）是生物学中铁（II）物种通过 Fenton/Fenton 样反应产生的，可以氧化损伤生物分子，诱导氧化应激和疾病。然而，这种普遍的认识最近受到了质疑，因为在铁（II）-碳酸盐配合物的 Fenton 样反应中观察到了碳酸根自由基。在此，我们报告铁（II）-组氨酸配合物的 Fenton 样反应可以在中性 pH 下发生，生成˙OH，而不是铁（IV）。我们的研究结果和对相关研究的批判性分析澄清了上述疑问，揭示了铁（II）物种引起氧化应激的新途径，并对阿尔茨海默病有影响。
